Plant-inspired adhesive and injectable natural hydrogels: in vitro and in vivo studies

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dc.authorid0000-0002-6361-4419tr
dc.contributor.authorDinçer, Emine
dc.contributor.authorÖksüz, Kerim Emre
dc.contributor.authorBohórquez-Moreno, Cristian Daniel
dc.date.accessioned2024-03-08T05:54:20Z
dc.date.available2024-03-08T05:54:20Z
dc.date.issued2023tr
dc.departmentSağlık Bilimleri Fakültesitr
dc.description.abstractThe development of alternative therapeutic treatments based on the use of medicinal and aromatic plants, such as Juniper communis L., has aroused interest in the medical feld to fnd new alternatives to conventional therapeutic treatments, which have shown problems related to bacterial resistance, high costs, or sustainability in their production. The present work describes the use of hydrogels based on sodium alginate and carboxymethyl cellulose, with combinations of juniperus leaves and berry extracts, in order to characterize their chemical characteristics, antibacterial activity, tissue adhesion test, cytotoxicity in the L929 cell line, and their efects on an in vivo model in mice to maximize the use of these materials in the healthcare feld. Overall, an adequate antibacterial potential against S. aureus, E. coli and P. vulgaris was obtained with doses above 100 mg.mL−1 of hydrogels. Likewise, low cytotoxicity in hydrogels combined with extracts has been identifed according to the IC50 value at 17.32 µg.mL−1, compared to the higher cytotoxic activity expressed by the use of control hydrogels with a value at 11.05 µg.mL−1. Moreover, in general, the observed adhesion was high to diferent tissues, showing its adequate capacity to be used in diferent tissue typologies. Furthermore, the invivo results have not shown erythema, edema, or other complications related to the use of the proposed hydrogels. These results suggest the feasibility of using these hydrogels in biomedical applications given the observed safety.tr
dc.identifier.doi10.1007/s10529-023-03400-zen_US
dc.identifier.endpage1222tr
dc.identifier.issn0141-5492 / 1573-6776
dc.identifier.issue9tr
dc.identifier.pmid37308681en_US
dc.identifier.scopus2-s2.0-85161607977en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage1209tr
dc.identifier.urihttps://hdl.handle.net/20.500.12418/14997
dc.identifier.volume45tr
dc.identifier.wosWOS:001004829200001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERtr
dc.relation.ispartofBiotechnology Lettersen_US
dc.relation.publicationcategoryUluslararası Editör Denetimli Dergide Makaletr
dc.rightsinfo:eu-repo/semantics/openAccesstr
dc.subjectBiological activitytr
dc.subjectBioadhesive injectable hydrogeltr
dc.subjectIn-vivo skin irritationtr
dc.subjectJuniperus communistr
dc.subjectMedicinal plantstr
dc.subjectTissue engineeringtr
dc.titlePlant-inspired adhesive and injectable natural hydrogels: in vitro and in vivo studiesen_US
dc.typeArticleen_US

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