Changes in Plasma Amino Acid Levels in Crimean-Congo Hemorrhagic Fever Patients

Basit Öğe Kaydı
dc.authoridErtemur, Zeynep/0000-0002-7365-9581
dc.contributor.authorErtemur, Zeynep
dc.contributor.authorAydin, Huseyin
dc.contributor.authorEngin, Aynur
dc.date.accessioned2024-10-26T18:09:26Z
dc.date.available2024-10-26T18:09:26Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: Crimean Congo Hemorrhagic Fever (CCHF) has an important place in viral hemorrhagic fever. Plasmaaminoacid (AA)levels of patientswhowerediagnosedwith CCHF in the acute and convalescent period of the disease were investigated in this study. Methods: 35 patients were included in the study specific polymerase chain reaction (PCR) and/or IgM antibody positivity for CCHF virus. AA levels were measured in the plasma derived from the blood samples of the patient and control groups, using liquid chromatography-mass spectrometry (LC-MS/MS) technique. Results: In our study, we observed that plasma aspartate, glutamate, histidine, leucine, phenylalanine, tyrosine levels increased statistically significantly (p<0.05), while some AAlevelsdecreased(p<0.05)inacutestagepatientscomparedtothecontrolgroups.In addition,whiletherewasanincreaseinplasmaglutamatelevelsofconvalescentpatients compared to the control groups (p<0.05), there was a significant decrease in other AA levels (p<0.05). Conclusion: Further studies to investigate the relationship between increased or decreased AAs in the plasma levels of these patients and the immune system are likely to contribute to a better understanding of the pathogenesis of the disease and to guide the approach to whether AA supplementation is necessary for treatment.
dc.identifier.doi10.58600/eurjther2112
dc.identifier.issn2564-7784
dc.identifier.issn2564-7040
dc.identifier.trdizinid1282366
dc.identifier.urihttps://doi.org/10.58600/eurjther2112
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30097
dc.identifier.wosWOS:001234168100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherPera Yayincilik Hizmetleri
dc.relation.ispartofEuropean Journal of Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbiochemical analysis
dc.subjectCrimean-Congo hemorrhagic fever virus
dc.subjectmetabolic analysis
dc.subjectresearch andanalysis methods
dc.titleChanges in Plasma Amino Acid Levels in Crimean-Congo Hemorrhagic Fever Patients
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu