Investigation of in vitro and in vivo therapeutic activity of Tarantula cubensis extract (Theranekron®) on Leishmania major

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dc.contributor.authorAkyol, Elif
dc.contributor.authorPolat, Zubeyda Akin
dc.date.accessioned2025-05-04T16:45:37Z
dc.date.available2025-05-04T16:45:37Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground objectives: Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease caused by several species of the protozoan parasite Leishmania. The need for new anti-leishmanial drugs for the treatment of CL is highlighted by factors such as high cost, toxicity, potential for resistance and limited long-term use of existing anti-leishmanial drugs. The aim of this study was to investigate the therapeutic effect of Tarantula cubensis alcoholic extract (TCE), which has been shown to have wound-healing, anti-inflammatory, regenerative, resolving and epithelialising effects, on L. major promastigotes in vitro and in vivo in an experimental mouse model of CL. Methods: The effect of TCE on L. major promastigotes in vitro was investigated after determination of non-cytotoxic concentrations of TCE using the XTT method. To establish a CL model, L. major amastigotes were injected into the paws of BALB/c mice. Lesion size and histopathological evaluation were used to assess the effect of treatment. Results: TCE was found to be effective against L. major promastigotes at 24 h and 48 h at concentrations of 250 mu g/mL, 125 mu g/mL and 62.5 mu g/mL ( P <0.05). TCE was found to be more effective than meglumine antimonate in treating CL in the experimentally induced CL model in BALB/c mice. Interpretation conclusion: The results suggest that TCE holds promising potential therapeutic agent for the treatment of CL. However, further extensive investigations are required to substantiate and expand understanding in this area.
dc.identifier.doi10.4103/0972-9062.392268
dc.identifier.endpage600
dc.identifier.issn0972-9062
dc.identifier.issue4
dc.identifier.pmid38842533
dc.identifier.scopus2-s2.0-85213866310
dc.identifier.scopusqualityQ4
dc.identifier.startpage594
dc.identifier.urihttps://doi.org/10.4103/0972-9062.392268
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35156
dc.identifier.volume61
dc.identifier.wosWOS:001364814300005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofJournal of Vector Borne Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250504
dc.subjectZiziphus mauritiana
dc.subjectCulex quinquefasciatus
dc.subjectAedes aegypti
dc.subjectMethanolic extract
dc.subjectLarvicidal and Pupicidal activity
dc.titleInvestigation of in vitro and in vivo therapeutic activity of Tarantula cubensis extract (Theranekron®) on Leishmania major
dc.typeArticle

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