Evaluation of potential cytotoxic and apoptotic effects of bioymifi on human multiple myeloma cell lines

Basit Öğe Kaydı
dc.contributor.authorTerzi, Hatice
dc.contributor.authorErgul, Merve
dc.date.accessioned2024-10-26T18:03:50Z
dc.date.available2024-10-26T18:03:50Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractPurpose: To investigate the cytotoxic and apoptotic activities of bioymifi (DR5 agonist) on bortezomibsensitive and bortezomib-resistant cells. Methods: The cytotoxic activities of bioymifi against bortezomib-sensitive (U266) and bortezomib-resistant (U266/BR) cells were evaluated using XTT cell viability test. The cells were exposed to increasing concentrations of bioymifi for 24 h. Cell cycle analysis was performed while apoptosis was examined by flow cytometry. Results: Bioymifi showed significant cytotoxic effects on 0266 and U266/BR in a concentration-dependent manner (p < 0.05). The IC50 values of bioymifi in U266 and U266/BR cells were 10.4 and 20.9 mu M, respectively. Moreover, when compared to the untreated cells, bioymifi treatment at IC50 concentrations considerably increased the percentage of apoptotic cells. Bioymifi treatment also caused cell cycle arrest at the G2/M phase in both cell types. Conclusion: The results show that bioymifi is a promising candidate for multiple myeloma treatment. However, further studies are required to evaluate the clinical anticancer activity of this agent.
dc.identifier.doi10.4314/tjpr.v19i11.17
dc.identifier.endpage2367
dc.identifier.issn1596-5996
dc.identifier.issue11
dc.identifier.scopus2-s2.0-85097161544
dc.identifier.scopusqualityQ3
dc.identifier.startpage2363
dc.identifier.urihttps://doi.org/10.4314/tjpr.v19i11.17
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28594
dc.identifier.volume19
dc.identifier.wosWOS:000595154800017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPharmacotherapy Group
dc.relation.ispartofTropical Journal of Pharmaceutical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBioymifi
dc.subjectMultiple myeloma
dc.subjectCytotoxicity
dc.subjectApoptosis
dc.subjectCell cycle
dc.subjectG2/M phase
dc.titleEvaluation of potential cytotoxic and apoptotic effects of bioymifi on human multiple myeloma cell lines
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu