Predictive markers of metabolically healthy obesity in children and adolescents: can AST/ALT ratio serve as a simple and reliable diagnostic indicator?

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dc.authoridtastanoglu, huseyin/0000-0002-6034-9998
dc.contributor.authorCelik, Nurullah
dc.contributor.authorUnsal, Gulsah
dc.contributor.authorTastanoglu, Huseyin
dc.date.accessioned2024-10-26T18:03:52Z
dc.date.available2024-10-26T18:03:52Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThis study aimed to estimate the prevalence of metabolically healthy obesity (MHO) according to two different consensus-based criteria and to investigate simple, measurable predictive markers for the diagnosis of MHO. Five hundred and ninety-three obese children and adolescents aged 6-18 years were included in the study. The frequency of MHO was calculated. ROC analysis was used to estimate the predictive value of AST/ALT ratio, waist/hip ratio, MPV, TSH, and Ft4 cut-off value for the diagnosis of MHO. The prevalence of MHO was 21.9% and 10.2% according to 2018 and 2023 consensus-based MHO criteria, respectively. AST/ALT ratio cut-off value for the diagnosis of MHO was calculated as >= 1 with 77% sensitivity and 52% specificity using Damanhoury et al.'s criteria (AUC = 0.61, p = 0.02), and 90% sensitivity and 51% specificity using Abiri et al.'s criteria (AUC = 0.70, p = 0.01). Additionally, using binomial regression analysis, only the AST/ALT ratio is independently and significantly associated with the diagnosis of MHO (p = 0.03 for 2018 criteria and p = 0.04 for 2023 criteria).Conclusion: The ALT/AST ratio may be a useful indicator of MHO in children and adolescents.What is Known:center dot Metabolically healthy obesity refers to people who are obese but do not have any of the standard cardio-metabolic risk factors.center dot Metabolically healthy obesity is not entirely harmless; the metabolic characteristics of individuals with this phenotype are less favorable than those of healthy lean groups. Moreover, it is not a constant state, and there may be a transition to metabolically unhealthy phenotypes over time.What is New:center dot The prevalence of MHO is 21.9% and 10.2% according to 2018 and 2023 consensus-based metabolically healthy obesity criteria, respectively.center dot The ALT/AST ratio may be a useful indicator of metabolically healthy obesity in children and adolescents.
dc.identifier.doi10.1007/s00431-023-05296-3
dc.identifier.endpage251
dc.identifier.issn0340-6199
dc.identifier.issn1432-1076
dc.identifier.issue1
dc.identifier.pmid37870612
dc.identifier.scopus2-s2.0-85174591265
dc.identifier.scopusqualityQ1
dc.identifier.startpage243
dc.identifier.urihttps://doi.org/10.1007/s00431-023-05296-3
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28627
dc.identifier.volume183
dc.identifier.wosWOS:001090687100005
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofEuropean Journal of Pediatrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMetabolically healthy obesity
dc.subjectCut-off level
dc.subjectAdolescent
dc.subjectObesity
dc.subjectAST/ALT ratio
dc.titlePredictive markers of metabolically healthy obesity in children and adolescents: can AST/ALT ratio serve as a simple and reliable diagnostic indicator?
dc.typeArticle

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