GC-MS Analysis, Antioxidant and Antifungal Studies of Different Extracts of Chaetomium globosum Isolated from Urginea indica

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dc.authoridattri, chandrika/0000-0001-5183-8645
dc.authoridSharifi-Rad, Javad/0000-0002-7301-8151
dc.contributor.authorKumari, Shailja
dc.contributor.authorKumari, Swati
dc.contributor.authorAttri, Chandrika
dc.contributor.authorSharma, Ruchi
dc.contributor.authorKulshreshtha, Sourabh
dc.contributor.authorBenali, Taoufiq
dc.contributor.authorBouyahya, Abdelhakim
dc.date.accessioned2024-10-26T18:11:05Z
dc.date.available2024-10-26T18:11:05Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractTo discover new natural resources with biological effects, the chemical investigation of antioxidant and antimicrobial activities of extract's Chaetomium globosum isolated from roots of Urginea indica. Gas chromatography-mass spectrometry (GC-MS) analysis demonstrated the presence of the major chemical constituents present in the methanol extract (1,3-oxathiolane, 1,3cyclopentadiene, 5-(1-methylethylidene), 5,9-hexadecadienoic acid, methyl ester, decane), chloroform extract (acetic acid, diethoxy-, ethyl ester, 2,2-bis(ethylsulfonyl)propane, 3-methyl-2-(2-oxopropyl) furan), and hexane extract (3-hexanone, 4,4dimethyl, decane,2,6-dimethyldecane, decane, 2,4,6-trimethyl, decane, 2,4,6-trimethyl, 1-butanesulfinamide, 1,1,2,2,3,3,4,4,4nonafluoro-N-methyl, decane). The total compound identified (56.2%) in chloroform extract, (54.72%) in hexane extract, and (65%) in methanol extract. The antioxidant effects were performed using diphenylpicrylhydrazyl radical (DPPH). The results showed that the methanol extract showed significantly the highest anti-DPPH with an IC50 value of 37.61 +/- 1.37 mu g/mL, followed by chloroform and hexane extracts with IC50 values of 40.82 +/- 3.60 and 45.20 +/- 2.54 mu g/mL, respectively. The antifungal activity of extracts was evaluated against pathogens fungi including Fusarium oxysporum, Rosellinia necatrix, Cladosporium xanthochromaticum, and Sclerotinia sclerotiorum. Methanolic and chloroform extracts showed maximum inhibition against all test pathogens, while hexane extract showed minimum inhibition.
dc.identifier.doi10.1155/2022/1388850
dc.identifier.issn2314-6133
dc.identifier.issn2314-6141
dc.identifier.pmid36624853
dc.identifier.scopus2-s2.0-85145957237
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1155/2022/1388850
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30506
dc.identifier.volume2022
dc.identifier.wosWOS:000911019500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHindawi Ltd
dc.relation.ispartofBiomed Research International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleGC-MS Analysis, Antioxidant and Antifungal Studies of Different Extracts of Chaetomium globosum Isolated from Urginea indica
dc.typeArticle

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