Noninvasive evaluation of cardiac autonomic modulation in children with primary Raynaud's phenomenon: a controlled study

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dc.authoridOflaz, Mehmet Burhan -- 0000-0003-1515-4654en_US
dc.contributor.authorOflaz, Mehmet Burhan
dc.contributor.authorEce, Ibrahim
dc.contributor.authorKibar, Ayse Esin
dc.contributor.authorBalli, Sevket
dc.contributor.authorAlaygut, Demet
dc.contributor.authorGuven, Ahmet Sami
dc.contributor.authorBolat, Fatih
dc.contributor.authorDuksal, Fatma
dc.contributor.authorCevit, Omer
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:58:09Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:58:09Z
dc.date.issued2014
dc.department[Oflaz, Mehmet Burhan] Cumhuriyet Univ, Sch Med, Dept Pediat Cardiol, Sivas, Turkey -- [Ece, Ibrahim] Yuzuncu Yil Univ, Sch Med, Dept Pediat Cardiol, Van, Turkey -- [Kibar, Ayse Esin] Mersin Children Hosp, Dept Pediat Cardiol, Mersin, Turkey -- [Balli, Sevket] Ataturk Hosp, Dept Pediat Cardiol, Balikesir, Turkey -- [Alaygut, Demet -- Guven, Ahmet Sami -- Bolat, Fatih] Cumhuriyet Univ, Sch Med, Dept Pediat, Sivas, Turkey -- [Duksal, Fatma -- Cevit, Omer] Cumhuriyet Univ, Sch Med, Dept Pediat Immunol & Rheumatol, Sivas, Turkey -- [Oflaz, Mehmet Burhan] Cumhuriyet Univ, Arastirma & Uygulama Hastanesi, Fac Med, Dept Pediat, TR-58140 Sivas, Turkeyen_US
dc.description.abstractThis study aimed to objectively evaluate autonomic nervous function in children with primary Raynaud's phenomenon (PRP). Thirty-two children with PRP and 30 healthy subjects were included in the study. We analyzed heart rate variability (HRV) in the time domain by the following six standard time-domain measures: standard deviation of all normal R-R intervals during 24 h (SDNN), standard deviation of all normal R-R intervals for all 5-min segments (SDNNi), standard deviation of the average normal R-R intervals for all 5-min segments (SDANN), root mean square of the successive normal R-R interval difference, percentage of successive normal R-R intervals longer than 50 ms, and triangular index (integral of the density distribution of NN intervals divided by the maximum of the density distribution). The mean heart rate throughout 24 h was significantly higher in the PRP group than in the control group (p = 0.001). Although heart rate during the activity period was not significantly different from that during the night period, it was higher in the PRP group than in the control group (p = 0.002). In children with PRP, HRV analysis showed significantly lower values of SDNN (p = 0.01), SDNNi (p = 0.005), SDANN (p = 0.02), and HRV triangular index (p = 0.02) compared with the control group. HRV analysis for sympathovagal balance demonstrated a preponderance for the sympathetic component in patients with PRP. We conclude that all time-domain parameters evaluated in HRV analysis are significantly lower in children with PRP than in healthy subjects.en_US
dc.identifier.doi10.1007/s10067-013-2393-1en_US
dc.identifier.endpage75en_US
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue1en_US
dc.identifier.pmid24077899en_US
dc.identifier.scopus2-s2.0-84900372388en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage71en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s10067-013-2393-1
dc.identifier.urihttps://hdl.handle.net/20.500.12418/8445
dc.identifier.volume33en_US
dc.identifier.wosWOS:000329941600010en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER LONDON LTDen_US
dc.relation.ispartofCLINICAL RHEUMATOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutonomic nervous systemen_US
dc.subjectChildrenen_US
dc.subjectHeart rate variabilityen_US
dc.subjectRaynaud's phenomenonen_US
dc.titleNoninvasive evaluation of cardiac autonomic modulation in children with primary Raynaud's phenomenon: a controlled studyen_US
dc.typeArticleen_US

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