PEGylated Titanium Dioxide Nanoparticle-bound Doxorubicin and Paclitaxel Drugs Affect Prostate Cancer Cells and Alter the Expression of DUSP Family Genes

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dc.authoridSilig, Yavuz/0000-0002-0562-7457
dc.authoridTAS, Ayca/0000-0002-7132-1325
dc.authoridayan, durmus/0000-0003-2615-8474
dc.authoridTUNCBILEK, ZUHAL/0000-0002-6510-0884
dc.contributor.authorTuncbilek, Zuhal
dc.contributor.authorCakmak, Nese Keklikcioglu
dc.contributor.authorTas, Ayca
dc.contributor.authorAyan, Durmus
dc.contributor.authorSilig, Yavuz
dc.date.accessioned2025-05-04T16:45:53Z
dc.date.available2025-05-04T16:45:53Z
dc.date.issued2025
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground PC is among the cancer types with high incidence and mortality. New and effective strategies are being sought for the treatment of deadly cancers, such as PC. In this context, the use of nanocarrier systems containing titanium dioxide can improve treatment outcomes and increase the effectiveness of anticancer drugs.Objective This study aimed to evaluate the cytotoxic activity of doxorubicin (DOX) and paclitaxel (PTX) drugs on the prostate cancer (PC) cell line by attaching them to pegylated titanium dioxide nanoparticles and to examine their effect on the expression levels of dual-specificity phosphatase (DUSP) genes.Methods Free DOX and PTX drugs, DOX and PTX compounds bound to the pegylated titanium dioxide system were applied to DU-145 cells, a PC cell line, under in vitro conditions, and MTT analysis was performed. Additionally, the IC50 values of these compounds were analyzed. In addition, the expression levels of DUSP1, DUSP2, DUSP4, DUSP6, and DUSP10 genes were measured using RT-PCR. Additionally, bioinformatics and molecular docking analyses were performed on DUSP proteins.Results The cytotoxic activity of PTX compound bound to PEGylated TiO2 was found to be higher than that of DOX compound bound to PEGylated TiO2. Additionally, when the expression levels were compared to the control group, the expression levels of DUSPs were found to be lower in the drugs of the drug carrier systems.Conclusion Accordingly, it was predicted that the pegylated titanium dioxide nano-based carrier could be effective in PC.
dc.identifier.doi10.2174/0118715206330115241015092548
dc.identifier.endpage271
dc.identifier.issn1871-5206
dc.identifier.issn1875-5992
dc.identifier.issue4
dc.identifier.pmid39473102
dc.identifier.scopus2-s2.0-86000263877
dc.identifier.scopusqualityQ2
dc.identifier.startpage257
dc.identifier.urihttps://doi.org/10.2174/0118715206330115241015092548
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35263
dc.identifier.volume25
dc.identifier.wosWOS:001345444200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofAnti-Cancer Agents in Medicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250504
dc.subjectProstate cancer
dc.subjectnano-based drug carrier
dc.subjectDUSPs
dc.subjectmolecular docking
dc.subjectgene expression
dc.subjectanticancer activity
dc.titlePEGylated Titanium Dioxide Nanoparticle-bound Doxorubicin and Paclitaxel Drugs Affect Prostate Cancer Cells and Alter the Expression of DUSP Family Genes
dc.typeArticle

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