Novel antimicrobial defensin peptides from different coleopteran insects (Coleoptera: Insecta): identification, characterisation and antimicrobial properties

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dc.authoridPEKTAS, AYSE NUR/0000-0001-5621-2844
dc.contributor.authorPektas, Ayse Nur
dc.contributor.authorKorkmaz, Ertan Mahir
dc.date.accessioned2025-05-04T16:46:55Z
dc.date.available2025-05-04T16:46:55Z
dc.date.issued2025
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractAntimicrobial peptides are crucial components of the immune systems of both vertebrates and invertebrates. Here, defensins, the most studied class of antimicrobial molecules in arthropods were investigated in four coleopteran insect species: Harpalus rufipes (DeGeer, 1774), Mylabris quadripunctata (Linnaeus, 1767), Sphaeridium marginatum (Linnaeus, 1758), and Ocypus mus (Brull & eacute;, 1832). The peptides synthesized with over 95% purity and their antimicrobial activities were evaluated by MIC test method. As a result, it was determined that Mylabris quadripunctata defensin (MqDef) showed high antimicrobial activity against Staphylococcus aureus and MRSA, whereas Sphaeridium marginatum (SmDef) and Harpalus rufipes (HrDef) defensins against Candida tropicalis.
dc.description.sponsorshipSivas Cumhuriyet University [CUBAP-F-555]
dc.description.sponsorshipThis study was financially supported by a grant from Sivas Cumhuriyet University (CUBAP-F-555). Laboratory facilities of Sivas Cumhuriyet University Advanced Technology Application and Research Centre (CUTAM) were used for the experiments.
dc.identifier.doi10.1080/10286020.2024.2448011
dc.identifier.issn1028-6020
dc.identifier.issn1477-2213
dc.identifier.pmid39786793
dc.identifier.scopus2-s2.0-85214680758
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1080/10286020.2024.2448011
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35411
dc.identifier.wosWOS:001392894100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Asian Natural Products Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250504
dc.subjectantimicrobial peptide
dc.subjectAMP
dc.subjectanticandidal activity
dc.subjectColeoptera
dc.subjectdefensin
dc.subjectMIC
dc.titleNovel antimicrobial defensin peptides from different coleopteran insects (Coleoptera: Insecta): identification, characterisation and antimicrobial properties
dc.typeArticle

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