Relationship between sacroiliitis and inflammatory markers in familial Mediterranean fever

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dc.authoridAtik, Irfan/0000-0002-9026-2076
dc.authoridAtik, Seda/0000-0002-7164-6592
dc.contributor.authorAtik, Irfan
dc.contributor.authorAtik, Seda
dc.date.accessioned2024-10-26T18:04:11Z
dc.date.available2024-10-26T18:04:11Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractOBJECTIVE: Familial Mediterranean fever is the most common monogenic autoinflammatory disease. This study aimed to evaluate the relationship between sacroiliitis observed in familial Mediterranean fever and hematological inflammatory markers. METHODS: In this study, 168 familial Mediterranean fever patients were examined. A total of 61 familial Mediterranean fever patients who had sacroiliac magnetic resonance imaging due to waist and hip pain were included in the study. According to the magnetic resonance imaging findings, patients were divided into two groups: with and without sacroiliitis. The relationship between hematological inflammatory markers and sacroiliitis was investigated. RESULTS: The frequency of sacroiliitis was found to be 13.6% in all familial Mediterranean fever patients and 37.8% in patients with low back pain who underwent sacroiliac magnetic resonance imaging. Neutrophil count, neutrophil/lymphocyte ratio, monocyte/lymphocyte ratio, and systemic immuneinflammatory index were significantly higher in the sacroiliitis group than in the other group, and this difference was found to be statistically significant (p<0.05). As a result of the receiver operating characteristic analysis, it was observed that neutrophil/lymphocyte ratio, monocyte/lymphocyte ratio, and systemic immune -inflammatory index were very sensitive parameters in determining sacroiliitis in patients with familial Mediterranean fever. CONCLUSION: It was observed that the frequency of sacroiliitis was increased in familial Mediterranean fever patients. It is predicted that hematological inflammatory markers such as neutrophil/lymphocyte ratio, monocyte/lymphocyte ratio, and systemic immune -inflammatory index can be used in the diagnosis of sacroiliitis.
dc.identifier.doi10.1590/1806-9282.20240068
dc.identifier.issn0104-4230
dc.identifier.issn1806-9282
dc.identifier.issue5
dc.identifier.pmid38775516
dc.identifier.scopus2-s2.0-85193609352
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1590/1806-9282.20240068
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28781
dc.identifier.volume70
dc.identifier.wosWOS:001229446300009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAssoc Medica Brasileira
dc.relation.ispartofRevista Da Associacao Medica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFamilial Mediterranean fever
dc.subjectInflammation
dc.subjectSacroiliitis
dc.titleRelationship between sacroiliitis and inflammatory markers in familial Mediterranean fever
dc.typeArticle

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