Relationship of Plasma Cell Infiltration Rates with 18F-FDG PET/CT Data and Hematological Parameters in Multiple Myeloma

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dc.contributor.authorBabacan, Ozge Ulas
dc.contributor.authorHasbek, Zekiye
dc.contributor.authorTerzi, Hatice
dc.date.accessioned2025-05-04T16:45:37Z
dc.date.available2025-05-04T16:45:37Z
dc.date.issued2025
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjectives: This study aimed to evaluate the relationship between the degree of bone marrow involvement, hematological parameters, and 18F-fluorodeoxyglucose (18F-FDG)-positron emission tomography/computed tomography (PET/CT) data in patients diagnosed with multiple Methods: A total of 71 patients [19 females, 52 males, mean age 67 (36-83) years] who were diagnosed with multiple myeloma between 2014 and 2021, had not received any treatment yet, and underwent 18F-FDG-PET/CT for staging were included in the study. Results: No significant correlation was observed between bone marrow standardized uptake value (SUV)max and plasma cell infiltration (p=0.07). However, we found that patients with visually increased bone marrow counts also had higher plasma cell infiltration rates (p=0.037). No significant correlation was found between plasma cell infiltration rates and bone marrow SUVmax and systemic inflammatory index (SII) (p=0.187 and p=0.446, respectively). However, there was a significant correlation between the SUVmax of lytic lesions showing increased 18F-FDG uptake in bone and SII (p=0.025, r=0.330). Conclusion: We believe that 18F-FDG PET/CT may be an advantage over bone marrow biopsy in the diagnosis and evaluation of multiple myeloma recurrence and may prevent repeated bone marrow biopsies.
dc.identifier.doi10.4274/mirt.galenos.2024.78557
dc.identifier.endpage30
dc.identifier.issn2146-1414
dc.identifier.issn2147-1959
dc.identifier.issue1
dc.identifier.pmid39918004
dc.identifier.scopus2-s2.0-85218167184
dc.identifier.scopusqualityQ3
dc.identifier.startpage26
dc.identifier.urihttps://doi.org/10.4274/mirt.galenos.2024.78557
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35149
dc.identifier.volume34
dc.identifier.wosWOS:001422765300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofMolecular Imaging and Radionuclide Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250504
dc.subjectMultiple myeloma
dc.subject18F-FDG PET/CT
dc.subjectplasma cell infiltration rate
dc.subjectsystemic immune-inflammatory index
dc.titleRelationship of Plasma Cell Infiltration Rates with 18F-FDG PET/CT Data and Hematological Parameters in Multiple Myeloma
dc.typeArticle

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