Evaluation of the clinical characteristics, laboratory parameters, and antibiotic treatment in patients diagnosed with tularemia

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dc.authoridaldemir, ozlem/0000-0002-9356-7510
dc.authoridKeskin, Ertugrul/0000-0002-8447-7695
dc.authoridfirtina topcu, kubra/0000-0002-3260-5309
dc.contributor.authorKiymaz, Yasemin cakir
dc.contributor.authorBolat, Serkan
dc.contributor.authorKatirci, Bilge
dc.contributor.authorAldemir, Ozlem
dc.contributor.authorAltinkaya, Isik
dc.contributor.authorOzcan, Merdan Mustafa
dc.contributor.authorHopoglu, Serhat Murat
dc.date.accessioned2025-05-04T16:47:10Z
dc.date.available2025-05-04T16:47:10Z
dc.date.issued2025
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIntroduction: This retrospective, cross-sectional, multi-center study aimed to evaluate the impact of laboratory results and treatments on the treatment response in patients diagnosed with tularemia. Methods: The study included 190 adult patients diagnosed with tularemia between November 2023 and June 2024. Results: 67.9 % were female, mean age was 45.8 +/- 14.9 years. The most frequently detected symptoms were sore throat (74.2 %), fatigue (71.6 %), and neck swelling (56.3 %). The most common form of tularemia was oropharyngeal (82.6 %) and glandular (14.2 %). The most used monotherapy was ciprofloxacin (80.5 %, n = 136), and combination therapy was streptomycin-ciprofloxacin (81.0 %, n = 17). Treatment failure was observed in 29 patients (15.2 %). No difference was found between patients who responded and didn't respond to treatment regarding laboratory parameters. Lymph node drainage or excision was performed in 47 patients (23 %). Suppurative lymphadenitis, abscess, necrosis, and conglomerate lymphadenopathy were more common in the lymph node drainage group. Reactive lymph nodes were more common in the group without lymph node drainage. There was no difference between the two groups regarding laboratory parameters of patients with and without lymph node drainage. The duration of antibiotic treatment was longer in patients who underwent lymph node drainage than in those who didn't. Conclusion: Radiological evaluation of lymph nodes upon hospital admission, in addition to antibiotic therapy during treatment, may help predict which patients are more likely to require surgical drainage. Laboratory parameters may not provide significant benefits in predicting the need for lymph node drainage and long-term treatment did not affect the treatment response.
dc.identifier.doi10.1016/j.jiac.2024.10.014
dc.identifier.issn1341-321X
dc.identifier.issn1437-7780
dc.identifier.issue2
dc.identifier.pmid39481537
dc.identifier.scopus2-s2.0-85207809344
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.jiac.2024.10.014
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35511
dc.identifier.volume31
dc.identifier.wosWOS:001401002800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Infection and Chemotherapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250504
dc.subjectFrancisella tularensis
dc.subjectLymphadenopathy
dc.subjectTularemia
dc.subjectTreatment outcome
dc.subjectDrainage
dc.titleEvaluation of the clinical characteristics, laboratory parameters, and antibiotic treatment in patients diagnosed with tularemia
dc.typeArticle

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