Evaluation of Serum Perforin, Caspase-3, sFasL and M-30 Levels as Apoptotic Markers in Children With Crimean-Congo Hemorrhagic Fever

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dc.authoridOflaz, Mehmet Burhan -- 0000-0003-1515-4654en_US
dc.contributor.authorGuven, Ahmet S.
dc.contributor.authorSancakdar, Enver
dc.contributor.authorUysal, Elif B.
dc.contributor.authorKaya, Ali
dc.contributor.authorOflaz, Mehmet B.
dc.contributor.authorKarapinar, Hekim
dc.contributor.authorBolat, Fatih
dc.contributor.authorTuzcu, Nevin
dc.contributor.authorDeveci, Koksal
dc.contributor.authorCevit, Omer
dc.contributor.authorIcagasioglu, Fusun D.
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:56:20Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:56:20Z
dc.date.issued2015
dc.department[Guven, Ahmet S. -- Kaya, Ali -- Oflaz, Mehmet B. -- Bolat, Fatih -- Cevit, Omer -- Icagasioglu, Fusun D.] Cumhuriyet Univ, Fac Med, Dept Pediat, TR-58140 Sivas, Turkey -- [Sancakdar, Enver -- Deveci, Koksal] Cumhuriyet Univ, Fac Med, Dept Biochem, TR-58140 Sivas, Turkey -- [Uysal, Elif B.] Cumhuriyet Univ, Fac Med, Dept Microbiol, TR-58140 Sivas, Turkey -- [Karapinar, Hekim] Cumhuriyet Univ, Fac Med, Dept Cardiol, TR-58140 Sivas, Turkey -- [Tuzcu, Nevin] Cumhuriyet Univ, Fac Pharm, Dept Pharmaceut Microbiol, TR-58140 Sivas, Turkeyen_US
dc.description.abstractBackground: Apoptosis is a main regulator in responses of cellular immunity throughout systemic viral infections. Perforin, soluble Fas ligand, caspase-3 and caspase-cleaved cytokeratin-18 (M-30) are mediators of apoptosis. The aim of this study is the evaluation of Crimean-Congo hemorrhagic fever (CCHF) disease changes in the levels of these apoptotic markers and the relation of these changes with disease severity. Methods: Forty-nine hospitalized children with CCHF and 36 healthy controls were enrolled in this prospective study. The CCHF patients were classified into 2 groups based on disease severity (severe group and nonsevere group). Demographic characteristics and clinical and laboratory findings of all patients were recorded on admission. Results: Serum perforin, caspase-3 and soluble Fas ligand levels were found to be significantly higher both in the severe and nonsevere CCHF groups than the healthy control group (P < 0.05), but there was no significant difference in these apoptotic markers between severe and nonsevere CCHF groups (P > 0.05). In addition, serum M-30 levels did not differ significantly among all groups (P > 0.05). There was a positive correlation between serum values for perforin, caspase-3 and M-30 and the disease's severity criteria such as aspartate aminotransferase and/or alanine aminotransferase. The serum levels of all these markers were negatively correlated with disease severity criteria such as the platelet count. Conclusions: In this study, we concluded that the interactions of cytolytic granules containing perforin and caspase cascade and Fas-FasL may play an important role in the pathogenesis of CCHF in children.en_US
dc.description.sponsorshipCumhuriyet University BAP [T-539]en_US
dc.description.sponsorshipThis study was supported by the Cumhuriyet University BAP with project number: T-539. The authors thank the Refik Saydam National Public Health Agency, a national reference laboratory in Turkey, for testing the serum samples.en_US
dc.identifier.doi10.1097/INF.0000000000000530en_US
dc.identifier.endpage213en_US
dc.identifier.issn0891-3668
dc.identifier.issn1532-0987
dc.identifier.issue2en_US
dc.identifier.pmid25170551en_US
dc.identifier.scopus2-s2.0-84925390202en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage208en_US
dc.identifier.urihttps://dx.doi.org/10.1097/INF.0000000000000530
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7956
dc.identifier.volume34en_US
dc.identifier.wosWOS:000349908800020en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofPEDIATRIC INFECTIOUS DISEASE JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectperforinen_US
dc.subjectsoluble Fas liganden_US
dc.subjectcaspase-3en_US
dc.subjectM-30en_US
dc.subjectapoptosisen_US
dc.subjectchildrenen_US
dc.subjectCrimean-Congo hemorrhagic feveren_US
dc.titleEvaluation of Serum Perforin, Caspase-3, sFasL and M-30 Levels as Apoptotic Markers in Children With Crimean-Congo Hemorrhagic Feveren_US
dc.typeArticleen_US

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