Antimicrobially effective protein-loaded metal chelated chitosan composite

Basit Öğe Kaydı
dc.authorid0000-0001-9139-1884tr
dc.contributor.authorAkkaya, Birnur
dc.contributor.authorAkkaya, Recep
dc.contributor.authorTaşkın Kafa Ayşe Hümeyra
dc.date.accessioned2024-02-27T11:55:28Z
dc.date.available2024-02-27T11:55:28Z
dc.date.issued2023tr
dc.departmentFen Fakültesitr
dc.description.abstractThe immobilization of lysozyme onto a novel synthetic metal chelator composite based on chitosan/PAA-PMA (chitosan/acrylamide-maleic acid) and its effect on antimicrobial activity were the aim of the current study. The plain composite and the lysozyme immobilized composite were characterized according to scanning electron microscopy (SEM), Ultraviolet spectroscopy (UV), Fourier transform infrared (FT-IR), and X-ray diffraction (XRD) analysis. Furthermore, the activities of lysozyme and immobilized lysozyme were investigated, as well as their antimicrobial activity against Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterococcus faecalis, and Staphylococcus aureus, as well as their cytotoxic effects, which were both approximately greater than those of free lysozyme. The last step was cytotoxic studies on lysozyme, chitosan composite, and lysozyme-immobilized chitosan composite, which showed no cytotoxic effect. Several investigations have shown that metal chelators improve lysozyme’s antibacterial action. Two carboxylic acids containing maleic acid were used as a metal chelator in this study. Lysozyme was immobilized from a side other than carboxylic acids, so that carboxylic acid groups, which are metal chelating groups, do not prevent synergy by competing with metal binding at neutral pH. This enhanced antimicrobial activity.tr
dc.description.sponsorship...tr
dc.identifier.citation...tr
dc.identifier.doi10.1515/polyeng-2023-0060en_US
dc.identifier.endpage758tr
dc.identifier.issue8tr
dc.identifier.scopus2-s2.0-85167447593en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage748tr
dc.identifier.urihttps://www.degruyter.com/document/doi/10.1515/polyeng-2023-0060/html
dc.identifier.urihttps://hdl.handle.net/20.500.12418/14372
dc.identifier.volume13tr
dc.identifier.wosWOS:001040706900001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherJournal of Polymer Engineeringtr
dc.relation.ispartofJournal of Polymer Engineeringen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıtr
dc.rightsinfo:eu-repo/semantics/openAccesstr
dc.subjectantibacterial activity, chitosan, cytotoxic effect, lysozyme, metal-chelatingtr
dc.titleAntimicrobially effective protein-loaded metal chelated chitosan compositeen_US
dc.typeArticleen_US

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