The water soluble ball-type phthalocyanine as new potential anticancer drugs

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dc.contributor.authorYabas, Ebru
dc.contributor.authorBagda, Efkan
dc.contributor.authorBagda, Esra
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:48:04Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:48:04Z
dc.date.issued2015
dc.department[Yabas, Ebru] Cumhuriyet Univ, Fac Sci, Dept Chem, Sivas, Turkey -- [Bagda, Efkan] Cumhuriyet Univ, Fac Sci, Dept Mol Biol & Genet, Sivas, Turkey -- [Bagda, Esra] Cumhuriyet Univ, Fac Pharm, Dept Analyt Chem, Sivas, Turkeyen_US
dc.description.abstractCompound 1 has been prepared by the reaction of 4-nitrophthalonitrile with triethanolamine. Compound 3 has been synthesized with quaternarization of compound 2 which prepared by cyclotetramerization of compound 1. The synthesized compounds have been characterized by elemental analysis, H-1 NMR, UV Vis, IR and MALDI-TOF MS spectral data. The interaction of compound 3 with calf thymus DNA was investigated spectrophotometrically. The phthalocyanine-DNA binding mechanism as well as the thermodynamic properties of binding was studied. The thermal denaturation profile, gel electrophoresis studies and the viscosity experiments were also conducted to clarify the mechanism. The replacement of ethidium bromide with phthalocyanine was monitored flourometrically to verify the binding mode. The Stern Volmer plot has nonlinear characteristic that implies both collisions of molecules and formation of ground state complexes which causes the fluorescence quenching. The experimental results indicate that the synthesized ball type water soluble phthalocyanine binds to calf thymus DNA via mainly intercalation. (C) 2015 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.dyepig.2015.03.038en_US
dc.identifier.endpage227en_US
dc.identifier.issn0143-7208
dc.identifier.issn1873-3743
dc.identifier.scopus2-s2.0-84929453567en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage220en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.dyepig.2015.03.038
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7759
dc.identifier.volume120en_US
dc.identifier.wosWOS:000356747300029en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherELSEVIER SCI LTDen_US
dc.relation.ispartofDYES AND PIGMENTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPhthalocyanineen_US
dc.subjectDNA bindingen_US
dc.subjectct-DNAen_US
dc.subjectThermodynamicen_US
dc.subjectViscosityen_US
dc.subjectAnticancer drugen_US
dc.titleThe water soluble ball-type phthalocyanine as new potential anticancer drugsen_US
dc.typeArticleen_US

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