Investigation of the in vitro effects of benzimidazol-2-ylidene-based silver-N-heterocyclic carbene complexes on Microsporidia and Leishmania major promastigotes

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dc.authoridSAHIN, Neslihan/0000-0003-1498-4170
dc.authoridOzdemir, Namik/0000-0003-3371-9874
dc.authoridGulpinar, Derya Gul/0000-0003-1096-3700
dc.contributor.authorAtas, Ahmet Duran
dc.contributor.authorGuelpinar, Derya Guel
dc.contributor.authorPolat, Zuebeyda Akin
dc.contributor.authorOzdemir, Namik
dc.contributor.authorSahin, Neslihan
dc.date.accessioned2025-05-04T16:47:08Z
dc.date.available2025-05-04T16:47:08Z
dc.date.issued2025
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIn this study, chloro[1-methallyl-3-(2,3,5,6-tetramethylbenzyl)-5,6-dimethylbenzimidazole-2-ylidene]silver(I) (C24H30AgClN2) (2a), chloro[1-methallyl-3-(2,3,4,5,6-pentamethylbenzyl)-5,6-dimethylbenzimidazole-2ylidene]silver(I) (C25H32AgClN2) (2b), chloro[1-methallyl-3-(naphthylmethyl)benzimidazole-2-ylidene]silver(I) (C24H24AgClN2) (2c) were prepared, and characterized by FT-IR, NMR (1H, 13 C{ 1 H) spectroscopy and elemental analysis. In addition, the structures of 2a and 2b were elucidated by single crystal X-ray diffraction analysis. The study evaluated the cytotoxic potential of benzimidazole-2-ylidene-based silver-NHC complexes in vitro. These complexes were tested for their antimicrosporidial activity using E. intestinalis spores in human renal epithelial cell lines (HEK-293). Similarly, the effect on Leishmania major promastigotes was measured by metabolic activity or cell viability assessed by the tetrazolium reaction. The results of our investigation showed that all the compounds studied exhibited inhibitory effects on the proliferation of both L. major promastigotes and E. intestinalis spores. Complex 2b showed promising potent inhibitory activity to combat microsporidial infections. Complex 2a showed the highest level of activity as a potent anti-Leishmania agent.
dc.description.sponsorshipScientific Research Projects Unit of Ondokuz Mayimath;s University [PYO.FEN.1906.19.001]
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Unit of Ondokuz May & imath;s University (Project No: PYO.FEN.1906.19.001) .
dc.identifier.doi10.1016/j.molstruc.2024.141153
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85213083914
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2024.141153
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35483
dc.identifier.volume1327
dc.identifier.wosWOS:001402531200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250504
dc.subjectSilver
dc.subjectN -heterocyclic carbene
dc.subjectEncephalitozoon intestinalis
dc.subjectMicrosporidia
dc.subjectLeishmania
dc.titleInvestigation of the in vitro effects of benzimidazol-2-ylidene-based silver-N-heterocyclic carbene complexes on Microsporidia and Leishmania major promastigotes
dc.typeArticle

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