Synthesis and anticancer activity of acyl thioureas bearing pyrazole moiety

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dc.contributor.authorKoca, Irfan
dc.contributor.authorOzgur, Aykut
dc.contributor.authorCoskun, Kubra Acikalin
dc.contributor.authorTutar, Yusuf
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:59:26Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:59:26Z
dc.date.issued2013
dc.department[Koca, Irfan] Bozok Univ, Fac Arts & Sci, Dept Chem, Yozgat, Turkey -- [Ozgur, Aykut -- Coskun, Kubra Acikalin] Gaziosmanpasa Univ, Fac Nat Sci & Engn, Dept Bioengn, Tokat, Turkey -- [Tutar, Yusuf] Cumhuriyet Univ, Fac Pharm, Dept Biochem, Sivas, Turkeyen_US
dc.description.abstractIn this work novel organic based compounds, acyl thiourea derivatives were synthesized and their anticancer activities were investigated. A new series of acyl thiourea derivatives containing pyrazole ring were prepared in good yield through one pot reaction of 4-benzoyl-1, 5-diphenyl-1H-pyrazole-3-carbonyl chloride with ammonium thiocyanate and various amines. The structures of the newly synthesized compounds were confirmed by IR, H-1 NMR, C-13 NMR and elemental analysis. Anticancer activities of synthesized compounds were evaluated on human colon, liver and leukemia cancer cell lines. Cell culture studies have demonstrated significant toxicity of the compounds on the cell lines, and the levels of toxicity have altered in the presence of various side groups. These results confirm that novel pyrazolyl acyl thioureas derived compounds may be utilized for cancer treatment. Furthermore, these compounds have a great potential and significance for further investigations. (C)2013 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipTurkish National Academy of Sciences [TUBA GEBIP 2008-29]en_US
dc.description.sponsorshipWe deeply appreciate expert Mehmet Gilmus for helping on the analysis of IR spectra. This work was funded through a seed grant from the Turkish National Academy of Sciences (TUBA GEBIP 2008-29 for Y.T.).en_US
dc.identifier.doi10.1016/j.bmc.2013.04.021en_US
dc.identifier.endpage3865en_US
dc.identifier.issn0968-0896
dc.identifier.issn1464-3391
dc.identifier.issue13en_US
dc.identifier.pmid23664495en_US
dc.identifier.scopus2-s2.0-84878557722en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage3859en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.bmc.2013.04.021
dc.identifier.urihttps://hdl.handle.net/20.500.12418/8653
dc.identifier.volume21en_US
dc.identifier.wosWOS:000320347100024en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofBIOORGANIC & MEDICINAL CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPyrazoleen_US
dc.subjectAcyl thioureaen_US
dc.subjectAnticancer activityen_US
dc.subjectLiveren_US
dc.subjectColonen_US
dc.subjectLeukemia cell linesen_US
dc.titleSynthesis and anticancer activity of acyl thioureas bearing pyrazole moietyen_US
dc.typeArticleen_US

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