Evaluation of the cytotoxicity of ventilation tube, nasal packing, and spongostan used in ear-nose-throat surgeries

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dc.contributor.authorAltuntaş E.E.
dc.contributor.authorSümer Z.
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:14:55Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:14:55Z
dc.date.issued2011
dc.departmentAltuntaş, E.E., Department of Otorhinolaryngology, Cumhuriyet University School of Medicine, Sivas, TR-58140, Turkey -- Sümer, Z., Departments of Ear, Nose and Throat, Education and Research Hospital, Sivas, Turkeyen_US
dc.description.abstractPurpose: The aim of this study was to determine biocompatibility of spongostan, merocell, and ventilation tube using agar diffusion and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide tests in cell culture and to evaluate the results in terms of clinical practices. Materials and Methods: The experimental procedures involved in this study were approved by the Animal Ethics Committee of Cumhuriyet University (B.30.2.CUM.0.01.00-50/4), and the study was conducted following accepted guidelines for the care and use of laboratory animals for research. The present study was supported by Cumhuriyet University Scientific Research Projects (CUBAP) Project no T-408. L929 mouse fibroblast cell culture was used in the present study. In this study, indirect toxic effects of the leakage products from the materials were tested with the agar overlay test, and also direct toxic effects of leakage materials occurring at different time and leakage products from the materials were tested with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide test. Results: As a result of evaluating the 21 days' leakage material of the ventilation tube a moderate (+2), 24 and 48 h of leakage material of the merocell low degree and 24-hour leakage material of the spongostan limited cytotoxicity were found. Conclusion: Many biomaterials cytotoxicity study were found in the literature as well as in our study shown by MTT and agar diffusion tests they were not toxic.en_US
dc.description.sponsorshipAltuntaş, E.E.; Department of Otorhinolaryngology, Cumhuriyet University School of Medicine, Sivas, TR-58140, Turkey; email: ealtunta@yahoo.comen_US
dc.identifier.doi10.4103/0971-7749.94492en_US
dc.identifier.endpage154en_US
dc.identifier.issn0971-7749
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84863214444en_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage149en_US
dc.identifier.urihttps://dx.doi.org/10.4103/0971-7749.94492
dc.identifier.urihttps://hdl.handle.net/20.500.12418/5006
dc.identifier.volume17en_US
dc.identifier.wosWOS:000219021600002en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofIndian Journal of Otologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgar overlayen_US
dc.subjectCytotoxicityen_US
dc.subjectMerocellen_US
dc.subjectMtt testen_US
dc.subjectSpongostanen_US
dc.subjectVentilation tubeen_US
dc.titleEvaluation of the cytotoxicity of ventilation tube, nasal packing, and spongostan used in ear-nose-throat surgeriesen_US
dc.typeArticleen_US

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