Total oxidative stress, paraoxonase and arylesterase levels at patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma

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dc.authoridarici, mustafa kemal -- 0000-0002-6350-9723en_US
dc.contributor.authorDursan, Feyza
dc.contributor.authorOzec, Ayse Vural
dc.contributor.authorAydin, Huseyin
dc.contributor.authorTopalkara, Aysen
dc.contributor.authorDarsun, Ayhan
dc.contributor.authorToker, Mustafa Ilker
dc.contributor.authorErdogan, Haydar
dc.contributor.authorArici, Mustafa Kemal
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:47:43Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:47:43Z
dc.date.issued2015
dc.department[Dursan, Feyza -- Ozec, Ayse Vural -- Topalkara, Aysen -- Darsun, Ayhan -- Toker, Mustafa Ilker -- Erdogan, Haydar -- Arici, Mustafa Kemal] Cumhuriyet Univ, Sch Med, Dept Ophthalmol, TR-58140 Sivas, Turkey -- [Aydin, Huseyin] Cumhuriyet Univ, Sch Med, Dept Biochem, TR-58140 Sivas, Turkeyen_US
dc.description.abstractAIM: To investigate the oxidative stress status of the aqueous humor and serum of patients with pseudoexfoliation (PEX) syndrome and pseudoexfoliative glaucoma (PEG) and to measure paraoxonase (PON) and arylesterase (ARE) levels. METHODS: A total of 78 patients were enrolled in the study, with 26 patients in each separate group. The patients were divided into three groups: the first group entailed PEX syndrome patients, while the second group consisted of patients with PEG and the third group involved patients with no additional systemic diseases, other than the diagnosis of cataract as control. Total oxidative stress (TOS), total antioxidant capacity (TAC), PON, and ARE levels in aqueous humor and serum were measured. RESULTS: TAC, PON and arylesterase levels in aqueous humor and serum of the PEX syndrome and PEG patients were significantly decreased compared with control group (P<0.05). TOS values were higher in patients with PEX syndrome and PEG than controls (P< 0.05). TAC, PON and ARE levels of aqueous humor did not differ significantly between the PEX syndrome and PEG groups CONCLUSION: These findings are potentially of significance and add to the growing body of evidence for oxidative stress in PEX syndrome and PEG. Decreased antioxidant defense and increased oxidative stress system may play an important role in the pathogenesis of PEX syndrome and PEG.en_US
dc.description.sponsorshipTurkish Ophthalmology Societyen_US
dc.description.sponsorshipThis study was supported by the Turkish Ophthalmology Society and our study was presented as a poster in the 16th Afro-Asian Congress of Ophthalmology and the 5th Mediterranean Retina Meeting.en_US
dc.identifier.doi10.3980/j.issn.2222-3959.2015.05.24en_US
dc.identifier.endpage990en_US
dc.identifier.issn2222-3959
dc.identifier.issn2227-4898
dc.identifier.issue5en_US
dc.identifier.pmid26558214en_US
dc.identifier.scopus2-s2.0-84944520304en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage985en_US
dc.identifier.urihttps://dx.doi.org/10.3980/j.issn.2222-3959.2015.05.24
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7713
dc.identifier.volume8en_US
dc.identifier.wosWOS:000361858600024en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIJO PRESSen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF OPHTHALMOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectpseudoexfoliation syndromeen_US
dc.subjectoxidative stressen_US
dc.subjectparaoxonaseen_US
dc.subjectarylesteraseen_US
dc.titleTotal oxidative stress, paraoxonase and arylesterase levels at patients with pseudoexfoliation syndrome and pseudoexfoliative glaucomaen_US
dc.typeArticleen_US

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