Impact of IL-6 rs1800795 and rs1800796 polymorphisms on clinical outcomes of COVID-19: a study on severity of disease in Turkish population

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dc.authoridAKIN, SEYDA/0000-0002-1194-6091
dc.authoridCekin, Nilgun/0000-0002-1000-7842
dc.authoridDOGAN, Halef Okan/0000-0001-8738-0760
dc.contributor.authorCekin, Nilgun
dc.contributor.authorAkin, Seyda
dc.contributor.authorPinarbasi, Ergun
dc.contributor.authorDogan, Okan Halef
dc.date.accessioned2025-05-04T16:47:27Z
dc.date.available2025-05-04T16:47:27Z
dc.date.issued2025
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractCoronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is exacerbated by cytokine storms, leading to severe inflammation. Interleukin-6 (IL-6) plays a critical role in this process, and variations in its promoter may influence disease severity. This study aims to investigate the relationship between IL6 promoter polymorphisms rs1800795 (G > C) and rs1800796 (G > C) and the severity of COVID-19 in the Turkish population. A total of 332 participants were included: 84 control, 80 with mild COVID-19, and 168 with severe COVID-19. IL6 polymorphisms were genotyped using the restriction fragment length polymorphism (RFLP) method. The genotypes rs1800795 GC (OR = 3.00, 95% CI: 1.669-5.398, p < 0.000), CC (OR = 7.44, 95% CI: 2.899-19.131, p < 0.000), and rs1800796 GC (OR = 2.76, 95% CI: 1.603-4.761, p < 0.000), as well as the alleles rs1800795 C (OR = 3.01, p < 0.000) and rs1800796 C (OR = 1.97, p = 0.002), may be associated with the severity of COVID-19. According to the Jonckheere-Terpstra (J-T) test, the most significant trends that vary linearly with disease severity were observed for D-dimer [J-T = 15.896, Effect size = 0.68 (0.61 to 0.76), p < 0.000] and CRP [J-T = 15.389, Effect size = 0.66 (0.59 to 0.73), p < 0.000]. The distribution of clinical parameters across genotype combinations (rs1800796/rs1800795*) showed that GC/GC* and GC/CC* were linked to a higher risk of severe inflammation, clotting, and organ damage. Additionally, it has been determined that the G-C and C-C haplotypes may be associated with increased severity of COVID-19. The rs1800795 and rs1800796 polymorphisms are linked to COVID-19 severity and could help guide future treatment strategies.
dc.description.sponsorshipSivas Cumhuriyet University Scientific Research Projects Unit (CUBAP) [T-2022-940]
dc.description.sponsorshipThis study was funded by Sivas Cumhuriyet University Scientific Research Projects Unit (CUBAP) (grant number: T-2022-940). Author C. Nilgun, A. Seyda, P. Ergun and H. D. Okan declare they have no financial interests.
dc.identifier.doi10.1007/s00335-024-10085-w
dc.identifier.endpage229
dc.identifier.issn0938-8990
dc.identifier.issn1432-1777
dc.identifier.issue1
dc.identifier.pmid39567384
dc.identifier.scopus2-s2.0-85209677032
dc.identifier.scopusqualityQ3
dc.identifier.startpage213
dc.identifier.urihttps://doi.org/10.1007/s00335-024-10085-w
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35627
dc.identifier.volume36
dc.identifier.wosWOS:001360957600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofMammalian Genome
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250504
dc.subjectCOVID-19
dc.subjectIL-6
dc.subjectPolymorphism
dc.subjectrs1800795
dc.subjectrs1800796
dc.subjectSeverity of disease
dc.subjectTurkish population
dc.titleImpact of IL-6 rs1800795 and rs1800796 polymorphisms on clinical outcomes of COVID-19: a study on severity of disease in Turkish population
dc.typeArticle

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