Benzaldehyde derivatives with functional propargyl groups as ?-glucosidase inhibitors

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dc.authoridgungor, seyit ali/0000-0002-3233-4529
dc.authoridtumer, mehmet/0000-0002-1882-429X
dc.contributor.authorGungor, Seyit Ali
dc.contributor.authorTumer, Mehmet
dc.contributor.authorKose, Muhammet
dc.contributor.authorErkan, Sultan
dc.date.accessioned2024-10-26T18:05:48Z
dc.date.available2024-10-26T18:05:48Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThe benzaldehyde derivatives (1-6) containing one and/or two propargyl arm(s) attached to the phenolic hydroxyl oxygen atom on the ortho-, meta- or para-positions of the aromatic ring were synthesized and characterized by spectral and microanalytical methods. The molecular structures were of 1, 4-6 determined by the single crystal X-ray crystallography. The benzaldehyde derivatives containing free phenolic groups involved intra- and inter-molecular hydrogen bonding interactions. The electrochemical properties of the compounds were investigated at the different scan rates and it was found that the compounds show different electrochemical behaviors. alpha-Glucosidase inhibitor properties of the carbonyl compounds were investigated and it has been determined that some of them show high activity. Compounds with a free phenolic group (-OH) exhibit better inhibition activity than compounds with no free phenolic group. It was also found that the position of propargyl group played an important role in the alpha-glucosidase inhibition activity. Molecular docking studies were performed to investigate the binding interactions and interaction energies of the (1-6) compounds with the alpha-glucosidase inhibitor. (C) 2020 Elsevier B.V. All rights reserved.
dc.description.sponsorship[2019/1-17D]; [2019/5-20 M]
dc.description.sponsorshipWe thank to Kahramanmaras Sutcu Imam University Science Project unit for the financial support for this study (Project Number: 2019/1-17D and 2019/5-20 M).
dc.identifier.doi10.1016/j.molstruc.2020.127780
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85078115644
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2020.127780
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29184
dc.identifier.volume1206
dc.identifier.wosWOS:000517780500005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHydroxy benzaldehyde
dc.subjectX-ray
dc.subjectElectrochemistry
dc.subjectalpha-Glucosidase
dc.subjectPropargyl
dc.subjectMolecular docking
dc.titleBenzaldehyde derivatives with functional propargyl groups as ?-glucosidase inhibitors
dc.typeArticle

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