A multicentre prospective analysis of the incidence of pemphigoid diseases in Turkey

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dc.authoridUzun, Soner/0000-0001-7059-5474
dc.authoridBozca, Burcin cansu/0000-0001-7907-5037
dc.authoridOKSUM SOLAK, EDA/0000-0002-1362-7801
dc.authoridOzcelik, Sinan/0000-0003-2115-276X
dc.authoridGURSEL URUN, Yildiz/0000-0002-6137-8395
dc.authoridAktan, Sebnem/0000-0002-0201-4663
dc.authoridYilmaz, Mustafa Anil/0000-0002-2069-1377
dc.contributor.authorDurdu, Murat
dc.contributor.authorBozca, Burcin Cansu
dc.contributor.authorEnli, Servinaz
dc.contributor.authorOzgen, Zuleyha Yazici
dc.contributor.authorYayli, Savas
dc.contributor.authorAktan, Sebnem
dc.contributor.authorMutlu, Derya
dc.date.accessioned2024-10-26T18:11:47Z
dc.date.available2024-10-26T18:11:47Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground: The differentiation between the pemphigoid diseases is essential for treatment and prognosis. In Turkey, data on the incidence of these diseases are insufficient. Our aim in this study is to determine the incidence, demographics and clinical characteristics associated with diseases of the pemphigoid group. Methods: We prospectively analysed 295 patients with pemphigoid who visited dermatology clinics of tertiary referral hospitals in 12 different regions of Turkey within a year. The diagnosis was based on clinical, histopathological, direct immunofluorescence (DIF) and serological (multivariant enzymelinked immunosorbent assay [ELISA], indirect immunofluorescence and mosaic-based BIOCHIP) examinations. Clinical and demographic findings, aetiological factors and concomitant diseases observed in the patients were recorded. Results: A total of 295 (female/male ratio: 1.7/1) patients with pemphigoid were diagnosed in 1-year period. The overall incidence rate of pemphigoid diseases was found to be 3.55 cases per millionyears. The ratio of pemphigoid group diseases to pemphigus group diseases was 1.6. The most common pemphigoid type was bullous pemphigoid (BP, 93.2%). The others were epidermolysis bullosa acquisita (3.1%), pemphigoid gestationis (2.4%), linear IgA disease (1%) and mucous membrane pemphigoid (0.3%). The most common (26.8%) possible trigger of the bullous pemphigoid was gliptin derivative drugs. The most common concomitant diseases with pemphigoid were cardiovascular (27.8%) and neurological diseases (23.7%). Conclusions: This study showed that the increased frequency of bullous pemphigoid reversed the pemphigoid/pemphigus ratio in Turkey. Further studies are warranted regarding the reasons for this increase.
dc.description.sponsorship'Research Project Support Scholarship' of the Turkish Dermatology Association [2019/259]; 'The Guided Project' of Akdeniz University Scientific Research Projects Unit [5212]
dc.description.sponsorshipThe study was supported by the `Research Project Support Scholarship' of the Turkish Dermatology Association (2019/259) and the `The Guided Project' of Akdeniz University Scientific Research Projects Unit (Project 5212).
dc.identifier.doi10.1111/ajd.13731
dc.identifier.endpageE503
dc.identifier.issn0004-8380
dc.identifier.issn1440-0960
dc.identifier.issue4
dc.identifier.pmid34642934
dc.identifier.scopus2-s2.0-85116932716
dc.identifier.scopusqualityQ2
dc.identifier.startpageE496
dc.identifier.urihttps://doi.org/10.1111/ajd.13731
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30823
dc.identifier.volume62
dc.identifier.wosWOS:000706544700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAustralasian Journal of Dermatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBullous pemphigoid
dc.subjectacquired epidermolysis bullosa
dc.subjectbenign mucous membrane pemphigoid
dc.subjectpemphigoid gestationis
dc.subjectincidence study
dc.titleA multicentre prospective analysis of the incidence of pemphigoid diseases in Turkey
dc.typeArticle

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