N-substituted benzenesulfonamide compounds: DNA binding properties and molecular docking studies
| dc.authorid | 0000-0001-6744-929X | tr |
| dc.contributor.author | Güngör, Seyit Ali | |
| dc.contributor.author | Tümer, Mehmet | |
| dc.contributor.author | Köse, Muhammet | |
| dc.contributor.author | Erkan, Sultan | |
| dc.date.accessioned | 2022-05-13T11:24:22Z | |
| dc.date.available | 2022-05-13T11:24:22Z | |
| dc.date.issued | Mart 2021 | tr |
| dc.department | Fen Fakültesi | tr |
| dc.description.abstract | Benzenesulfonamide-based imine compounds 5–8 were prepared and screened for their binding properties to the FSdsDNA. The structures of synthesized compounds were elucidated by the spectroscopic and analytical methods. Compounds 5–8 were screened for their interactions with the FSdsDNA. Compound 8 showed the highest binding affinity to the FSdsDNA with intrinsic binding constant of 3.10 × 104 M−1. The compounds caused the quenching of the DNA–EB emission indicating displacement of EB (ethidium bromide) from the FSdsDNA. Finally, the binding interactions between the DNA and binder molecules 5–8 were examined by the molecular docking studies. The compounds locate approximately same region of the minor groove of DNA via hydrogen bonding contacts between the sulfonamide oxygen atoms and the DG10/DG16 nucleotides of DNA. | tr |
| dc.identifier.citation | Seyit Ali Gungora , Mehmet Tumera , Muhammet Kosea and Sultan Erkanb a chemistry Department,K.MarasS€utc€u ImamUniversity,K.Maras,Turkey; b Department of Chemistry and Chemical Processing Technologies,Sivas CumhuriyetUniversityYıldızeli Vocational School,Sivas,Turkey | tr |
| dc.identifier.doi | 10.1080/07391102.2021.1897683 | en_US |
| dc.identifier.endpage | 15 | tr |
| dc.identifier.pmid | 33704019 | en_US |
| dc.identifier.scopus | 2-s2.0-85103260590 | en_US |
| dc.identifier.scopusquality | N/A | |
| dc.identifier.startpage | 1 | tr |
| dc.identifier.uri | https://www.tandfonline.com/doi/full/10.1080/07391102.2021.1897683 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12418/13051 | |
| dc.identifier.volume | 15 | tr |
| dc.identifier.wos | WOS:000628693200001 | en_US |
| dc.identifier.wosquality | Q1 | |
| dc.indekslendigikaynak | Web of Science | en_US |
| dc.indekslendigikaynak | Scopus | en_US |
| dc.indekslendigikaynak | PubMed | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Taylor&Francis | tr |
| dc.relation.ispartof | Journal of Biomolecular Structure and Dynamics | en_US |
| dc.relation.publicationcategory | Uluslararası Editör Denetimli Dergide Makale - Başka Kurum Yazarı | tr |
| dc.rights | info:eu-repo/semantics/openAccess | tr |
| dc.subject | Sulfonamide propargyl imine DNA molecular docking | tr |
| dc.title | N-substituted benzenesulfonamide compounds: DNA binding properties and molecular docking studies | en_US |
| dc.type | Article | en_US |
