Effects of polyamine synthesis enzymes on angiogenesis and apoptosis during endometriosis

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dc.contributor.authorYıldız, Çağlar
dc.contributor.authorÇelik, Veysel Kenan
dc.contributor.authorKurt, Begüm
dc.contributor.authorKapancık, Serkan
dc.contributor.authorKılıçgün, Hasan
dc.date.accessioned2024-03-06T09:12:06Z
dc.date.available2024-03-06T09:12:06Z
dc.date.issued2023tr
dc.departmentTıp Fakültesitr
dc.description.abstractObjectives: Since we assumed that endometriosis is a benign cell division disorder, our study was conducted to investigate the effects of the relationships between polyamine synthesis and angiogenesis in the formation of endometriosis. Material and methods: Thirty-five patients with endometriosis and 35 healthy female women were included in the study. The patient and the control groups were compared regarding the blood levels of agmatine, argininecarboxylase (ADC), ornithinecarboxylase (ODC), agmatinase, arginase, ornithine, and the vascular endothelial growth factor (VEGF). Results: There is a statistically significant difference between the patient and the control groups regarding the agmatinase, arginase and VEGF levels (higher in the patient group) (p < 0.05). There is no statistically significant difference between the patient and the control groups regarding the ODC, ornithine and the ADC levels (p > 0.05). There is a statistically significant difference between the patient and the control groups regarding the agmatine levels (higher in the control group) (p < 0.05). Conclusions: The increase in the serum levels of polyamine synthesis enzymes may contribute to the formation of endometriosis. It is anticipated that the study of the relationship between enzymes and molecules in the polyamine synthesis pathway and angiogenesis in patients with endometriosis will contribute to the literature.tr
dc.identifier.scopus2-s2.0-85149632252en_US
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://hdl.handle.net/20.500.12418/14733
dc.identifier.wosWOS:000939399500001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.publicationcategoryRaportr
dc.rightsinfo:eu-repo/semantics/openAccesstr
dc.titleEffects of polyamine synthesis enzymes on angiogenesis and apoptosis during endometriosisen_US
dc.typeArticleen_US

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