Synthesis and Antimicrobial Activity of Racemic 1,5-Diols: 2-(1,3-Diaryl-3-hydroxypropyl)cyclohexan-1-ol Derivatives

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dc.authoridGezegen, Hayreddin -- 0000-0003-3602-7400en_US
dc.contributor.authorGezegen, Hayreddin
dc.contributor.authorTutar, Ugur
dc.contributor.authorCeylan, Mustafa
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:45:02Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:45:02Z
dc.date.issued2016
dc.department[Gezegen, Hayreddin -- Tutar, Ugur] Cumhuriyet Univ, Dept Nutr & Dietet, Fac Hlth Sci, TR-58140 Sivas, Turkey -- [Ceylan, Mustafa] Gaziosmanpasa Univ, Fac Arts & Sci, Dept Chem, TR-60250 Tokat, Turkeyen_US
dc.description.abstractA series of novel racemic 2-(1,3-diaryl-3-hydroxypropyl)cyclohexan-1-ol derivatives were synthesized from 1,5-diketones. All the synthesized compounds were characterized by spectroscopic methods. The antibacterial activities of obtained chiral 1,5-diols were investigated against four Gram-positive and three Gram-negative bacteria by determining of minimum inhibitory concentrations (MICs) in vitro. Compounds 3b, 3c, and 3d were found to be active against Enterococcus faecalis and Escherichia coli. In addition, compound 3j were found to be moderately active against all tested bacterial strains.en_US
dc.description.sponsorshipGaziosmanpasa University [BAP-2011/94]en_US
dc.description.sponsorshipThe authors are indebted to the Gaziosmanpasa University (Grant BAP-2011/94) for financial support of this work.en_US
dc.identifier.doi10.1002/hlca.201600048en_US
dc.identifier.endpage616en_US
dc.identifier.issn0018-019X
dc.identifier.issn1522-2675
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-84982221105en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage608en_US
dc.identifier.urihttps://dx.doi.org/10.1002/hlca.201600048
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7238
dc.identifier.volume99en_US
dc.identifier.wosWOS:000383473800006en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWILEY-V C H VERLAG GMBHen_US
dc.relation.ispartofHELVETICA CHIMICA ACTAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChalconesen_US
dc.subject1en_US
dc.subject5-Diketone compoundsen_US
dc.subject1en_US
dc.subject5-Diolsen_US
dc.subjectMichael additionen_US
dc.subjectAntimicrobial activityen_US
dc.titleSynthesis and Antimicrobial Activity of Racemic 1,5-Diols: 2-(1,3-Diaryl-3-hydroxypropyl)cyclohexan-1-ol Derivativesen_US
dc.typeArticleen_US

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