In vitro biological activities and preliminary phytochemical screening of different extracts from Achillea sintenisii Hub- Mor

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dc.authoridUSTUN ALKAN, Fulya/0000-0003-1782-9467
dc.authoridDIREN SIGIRCI, BELGI/0000-0001-7153-7428
dc.contributor.authorAnlas, Ceren
dc.contributor.authorBakirel, Tulay
dc.contributor.authorUstuner, Oya
dc.contributor.authorUstun-Alkan, Fulya
dc.contributor.authorDiren-Sigirci, Belgi
dc.contributor.authorKoca-Caliskan, Ufuk
dc.contributor.authorMancak-Karakus, Methiye
dc.date.accessioned2024-10-26T18:09:31Z
dc.date.available2024-10-26T18:09:31Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThis study was designed to investigate in vitro biological activities and phytochemical composition of aqueous and ethanolic extracts from Achillea sintenisii Hub-Mor. (AS). To deter-mine the chemical composition of AS extracts, phytochemical analyses were performed by using HPLC-ESI-Q-TOF-MS-MS. Afterwards, both extracts were investigated in terms of their effect on fibroblast proliferation, collagen synthesis, and hydrogen peroxide-induced damage. In addition to cell culture analysis, antibacterial, antioxidant, hyaluronidase inhibitory activities and total phe-nolic contents of the extracts were analyzed in cell-free systems. Our results demonstrated that the aqueous and ethanolic extracts did not show cytotoxic activity on fibroblasts, on the contrary, pro-moted fibroblast proliferation. Both AS extracts potently inhibited hyaluronidase activity and the inhibitory effect of ethanolic extract was comparable with the positive control, especially at high concentrations. The aqueous extract was the potent stimulator of collagen synthesis at 200 mg/mL concentration. Although the ethanolic extract showed antibacterial activity against all gram -positive bacteria, the aqueous extract was only effective against K. pneumoniae and B. subtilis. The ability of AS extracts, which have a rich phenolic compound content (>= 50 mg GAE/g), to scav-enge free radicals and protect fibroblasts against hydrogen peroxide-induced damage can be consid-ered as a result of their antioxidant potential. Our findings scientifically support the widespread use of this plant, by demonstrating the pharmacological properties of the extracts.(c) 2022 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.description.sponsorshipDepartment of Scientific Research Projects, Istanbul University-Cerrahpasa, Turkey; [22886]
dc.description.sponsorshipFunding This work was supported by the Department of Scientific Research Projects, Istanbul University-Cerrahpasa, Turkey [Grant No: 22886] .
dc.identifier.doi10.1016/j.arabjc.2022.104426
dc.identifier.issn1878-5352
dc.identifier.issn1878-5379
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85143173395
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.arabjc.2022.104426
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30153
dc.identifier.volume16
dc.identifier.wosWOS:000916163500004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofArabian Journal of Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAchillea sintenisii
dc.subjectFibroblast proliferation
dc.subjectAntioxidant activity
dc.subjectAntibacterial activity
dc.subjectCollagen synthesis
dc.subjectHyaluronidase inhibitory activity
dc.titleIn vitro biological activities and preliminary phytochemical screening of different extracts from Achillea sintenisii Hub- Mor
dc.typeArticle

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