Examination of ototoxicity induced by imatinib, being a tyrosine kinase inhibitor: An experimental study

Basit Öğe Kaydı
dc.contributor.authorAltuntas, Emine Elif
dc.contributor.authorDurmus, Kasim
dc.contributor.authorBora, Adem
dc.contributor.authorTurgut, Nergiz Hacer
dc.contributor.authorTerzi, Hatice
dc.contributor.authorKutluhan, Ahmet
dc.date.accessioned2024-10-26T18:09:38Z
dc.date.available2024-10-26T18:09:38Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjectives: Two rats were excluded from the study. Because otitis media developing one rat in Group C (7th dayof the experiment) and bleeding-related death one rat in Group I-50 (14th day of the experiment). While the side effects of imatinib are investigated in the literature, it is remarkable that the case reports suggesting an ototoxic side effect also take place among the publications. The aim of this study was to investigate whether or not imatinib has any ototoxic effect on rats via auditory brainstem response (ABR) responses. Materials and Methods: Rats were divided into three groups as Group C (0.25 mL/kg/day), Group I-30 (30 mg/kg/day), and Group I-50 (50 mg/kg/day). In the ABR record, hearing threshold, latency, amplitude, and interpeak latency values on test days were recorded and assessed. Results: In the assessment made in terms of mean V Wave latency within the group, a difference was determined at all stimulus intensities at 8 kHz in Group I-50 (P < 0.05). In the within-group assessment performed in terms of mean Wave III latency, there were differences in Groups I-30 and I-50 (P < 0.05). In the within-group assessment performed in terms of I-III interpeak latency mean values, there was a difference at 4 kHz and 70 dB in Group I-30 (P < 0.05). In the within-group assessment in terms of mean III-V interpeak latency values, the difference between the groups was significant on the 7th day at 6 kHz and 50 dB (P = 0.044) and on the 14th day at 8 kHz and 70 dB (P = 0.036). In the within-group assessment in terms of Wave I amplitude mean values, the change in the amplitude values at 4 kHz (P = 0.003) and 6 kHz (P = 0.018) in Group I-50 was significant. Conclusion: It was observed that imatinib application caused elongation in latency and interpeak latency values and changes in amplitude values. These differences were not enough to state that imatinib is having an ototoxic side effect.
dc.identifier.doi10.4103/indianjotol.INDIANJOTOL_129_20
dc.identifier.endpage146
dc.identifier.issn0971-7749
dc.identifier.issn2249-9520
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85098641949
dc.identifier.scopusqualityQ4
dc.identifier.startpage141
dc.identifier.urihttps://doi.org/10.4103/indianjotol.INDIANJOTOL_129_20
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30196
dc.identifier.volume26
dc.identifier.wosWOS:000604253600006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofIndian Journal of Otology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAuditory brainstem response
dc.subjectimatinib
dc.subjecthearing loss
dc.subjectototoxicity
dc.subjectrat
dc.titleExamination of ototoxicity induced by imatinib, being a tyrosine kinase inhibitor: An experimental study
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu