The relationship between D-dimer level and the development of atrial fibrillation in patients with systolic heart failure

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dc.authoridYILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628; YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628en_US
dc.contributor.authorZorlu, Ali
dc.contributor.authorAkkaya, Emre
dc.contributor.authorAltay, Hakan
dc.contributor.authorBektasoglu, Gokhan
dc.contributor.authorTurkdogan, Kenan Ahmet
dc.contributor.authorSincer, Isa
dc.contributor.authorVuruskan, Ertan
dc.contributor.authorCinar, Ziynet
dc.contributor.authorTandogan, Izzet
dc.contributor.authorYilmaz, Mehmet Birhan
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:03:47Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:03:47Z
dc.date.issued2012
dc.department[Zorlu, Ali] Bulanik State Hosp, Dept Cardiol, Mus, Turkey -- [Akkaya, Emre -- Sincer, Isa -- Vuruskan, Ertan] Gaziantep State Hosp, Dept Cardiol, Gaziantep, Turkey -- [Altay, Hakan] Baskent Univ, Fac Med, Dept Cardiol, TR-06490 Ankara, Turkey -- [Bektasoglu, Gokhan -- Tandogan, Izzet -- Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Sch Med, Dept Cardiol, Sivas, Turkey -- [Turkdogan, Kenan Ahmet] Cumhuriyet Univ, Sch Med, Dept Emergency, Sivas, Turkey -- [Cinar, Ziynet] Cumhuriyet Univ, Sch Med, Dept Biostat, Sivas, Turkeyen_US
dc.description.abstractHeart failure (HF) is one of the most common and leading cause of death worldwide. Clinical trials provide evidence that the development of atrial fibrillation (AF) is a marker of poor prognosis in patients with HF. Furthermore, elevated D-dimer level is associated with increased cardiovascular mortality independent of AF in HF patients. We investigated whether plasma D-dimer levels in patients with hospitalized systolic HF could predict development of AF. A total of 150 consecutive patients with sinus rhythm who admitted to the emergency department with hospitalized systolic HF were evaluated. All hospitalized patients were obtained D-dimer levels within the first 24 h following admission. Atrial fibrillation developed in 31 (20.7%) patients during follow-up period of 6.3 +/- A 5 months. Patients who developed atrial fibrillation had significantly increased levels of D-dimer [608 (339-1,022) ng/ml versus 1,100 (608-2,599) ng/ml, P = 0.001]. Optimal cut-off level of D-dimer to predict development of AF was found to be > 792 ng/ml. D-dimer > 792 ng/ml, right ventricular dilatation, age, systolic pulmonary pressure, left atrium size, moderate to severe tricuspid regurgitation, and beta blocker usage were found to have prognostic significance in univariate analysis. In multivariate Cox proportional-hazards model, D-dimer levels > 792 ng/ml (HR = 3.019, P = 0.006), and right ventricular dilatation (HR = 8.676, P = 0.003) were associated with an increased risk of new-onset AF. In conclusion, D-dimer could predict development of AF in patients with hospitalized systolic HF.en_US
dc.identifier.doi10.1007/s11239-011-0656-8en_US
dc.identifier.endpage348en_US
dc.identifier.issn0929-5305
dc.identifier.issue4en_US
dc.identifier.pmid22139027en_US
dc.identifier.scopus2-s2.0-84865136496en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage343en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s11239-011-0656-8
dc.identifier.urihttps://hdl.handle.net/20.500.12418/9151
dc.identifier.volume33en_US
dc.identifier.wosWOS:000303508600007en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofJOURNAL OF THROMBOSIS AND THROMBOLYSISen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectD-dimeren_US
dc.subjectAtrial fibrillationen_US
dc.subjectHeart failureen_US
dc.titleThe relationship between D-dimer level and the development of atrial fibrillation in patients with systolic heart failureen_US
dc.typeArticleen_US

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