The role of C4d expression in the diagnosis of bullous pemphigoid: a clinical and histopathological study

Basit Öğe Kaydı
dc.authoridKAYA, SEYHMUS/0000-0003-4059-9946
dc.contributor.authorKaya, Seyhmus
dc.contributor.authorYuceer, Ramazan Oguz
dc.contributor.authorTosun, Mustafa
dc.contributor.authorMustafaeva, Reikhan
dc.date.accessioned2025-05-04T16:47:26Z
dc.date.available2025-05-04T16:47:26Z
dc.date.issued2025
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractInflammatory processes play a crucial role in both autoimmune and non-autoimmune skin diseases. The complement system contributes to these processes, with both well-established and yet-to-be-confirmed effects. The relationship between C4d, an intermediate product of the complement system, and skin diseases remains an area of ongoing investigation. While the presence and role of C4d in autoimmune and non-autoimmune skin diseases have been explored using immunohistochemical methods, the topic remains inconclusive. Bullous pemphigoid is an autoimmune skin disorder characterized by subepidermal blistering, predominantly affecting the elderly population. This study aims to evaluate the potential of C4d as an alternative immunohistochemical marker to the gold-standard diagnostic method, direct immunofluorescence, in diagnosing Bullous pemphigoid. Additionally, C4d staining patterns were analyzed in correlation with clinical data to assess its prognostic significance. In this retrospective study, the histomorphological, clinical, and demographic data of 43 patients diagnosed with Bullous pemphigoid were analyzed. Immunohistochemical assessment of C4d expression and staining patterns was conducted. The findings suggest that C4d may serve as a potential diagnostic and prognostic marker. C4d expression was significantly more frequent in lesions located on the upper extremities and in patients with higher eosinophil scores. Furthermore, patients with high eosinophil scores were more likely to receive systemic treatment. This study demonstrates that C4d could contribute significantly to the diagnostic process, particularly in cases where immunofluorescence studies are limited.
dc.identifier.doi10.1007/s00403-025-04031-2
dc.identifier.issn0340-3696
dc.identifier.issn1432-069X
dc.identifier.issue1
dc.identifier.pmid40095080
dc.identifier.scopus2-s2.0-105000382641
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s00403-025-04031-2
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35624
dc.identifier.volume317
dc.identifier.wosWOS:001447023300011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofArchives of Dermatological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250504
dc.subjectBullous pemphigoid
dc.subjectC4d
dc.subjectEosinophil
dc.subjectGliptin
dc.titleThe role of C4d expression in the diagnosis of bullous pemphigoid: a clinical and histopathological study
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksyonu
Scopus İndeksli Yayınlar Koleksiyonu