Association between thiol-disulfide hemostasis and transient tachypnea of the newborn in late-preterm and term infants

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dc.authoridErdal, Huseyin/0000-0003-0786-5077
dc.authoridDemirtas, Mehmet Semih/0000-0003-2965-1811
dc.authoridTunc, Gaffari/0000-0001-7837-3948
dc.authoridKilicbay, Fatih/0000-0001-9073-0864
dc.contributor.authorDemirtas, Mehmet Semih
dc.contributor.authorErdal, Huseyin
dc.contributor.authorKilicbay, Fatih
dc.contributor.authorTunc, Gaffari
dc.date.accessioned2024-10-26T18:09:15Z
dc.date.available2024-10-26T18:09:15Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackgroundTransient tachypnea of the newborn (TTN), which is the most common respiratory disease in the neonatal period, increases respiratory workload in newborns. We purposed to evaluate the oxidative stress (OS) status and thiol disulfide hemostasis in late preterm and term newborns with TTN in this study.MethodsThe study was carried out in a single-centre neonatal intensive care unit to investigate the effect of continuous airway positive pressure (CPAP) on the oxidative system in newborns with TTN. Thiol (native and total) and disulfide levels, total antioxidant and oxidant status (TAS/TOS) and Oxidative stress index (OSI) levels were measured.ResultsTotal thiol levels measured before treatment was 429.5 (369.5-487) mu mol/L in the late preterm group and 425 (370-475) mu mol/L in the term group (p = 0.741). We found significant changes in TOS, OSI and TAS levels after CPAP treatment in the late preterm group (p < 0.001, p < 0.001, p = 0.012 respectively). It was also found that the disulfide level, which was 26.2 (19.2-31.7) before the treatment, decreased to 19.5 (15.5-28.75) after the treatment (p = 0.001) in late preterms.ConclusionCPAP treatment reduced the OS status burden associated with TTN in neonates. The late preterm newborns with TTN are more affected by OS and increased OS levels decrease with CPAP treatment.
dc.identifier.doi10.1186/s12887-023-03936-z
dc.identifier.issn1471-2431
dc.identifier.issue1
dc.identifier.pmid36966275
dc.identifier.scopus2-s2.0-85150950010
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1186/s12887-023-03936-z
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30022
dc.identifier.volume23
dc.identifier.wosWOS:000953091500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmc
dc.relation.ispartofBmc Pediatrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTransient Tachypnea of the newborn (TTN)
dc.subjectLate preterm (34-36w)
dc.subjectThiol
dc.subjectOxidative stress
dc.subjectNewborn
dc.titleAssociation between thiol-disulfide hemostasis and transient tachypnea of the newborn in late-preterm and term infants
dc.typeArticle

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