Selective cytotoxicity of paclitaxel bonded silver nanoparticle on different cancer cells

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dc.authoriderdem kuruca, serap/0000-0001-7878-9994
dc.contributor.authorDanisman-Kalindemirtas, Ferdane
dc.contributor.authorKariper, I. Afsin
dc.contributor.authorHepokur, Ceylan
dc.contributor.authorErdem-Kuruca, Serap
dc.date.accessioned2024-10-26T18:09:00Z
dc.date.available2024-10-26T18:09:00Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractPaclitaxel (PTX) is one of the most effective drugs in the treatment of cancer. However, its usability is limited due to low solubility and side effects. In this study, we investigated anticancer effects of PTX bonded silver nanoparticles (AgNPs-PTX) on 4 different cancer cells, namely MDA-MB-231, MCF-7, 4T1, Saos-2, and on noncancerous HUVEC cells. The silver nanoparticles (AgNPs) that we synthesized were first characterized by UV-VIS, FTIR, SEM, and DLS analysis. The size of AgNPs was measured to be around 3 nm and AgNPs-PTX around 10 nm. AgNPs-PTX were found to be 2 to 10 times more effective than PTX alone. Especially, Saos-2 cells were found to be approximately 10 times more sensitive to AgNPs-PTX than PTX alone. AgNPs-PTX did not caused toxicity on non-cancerous HUVEC cell and significantly reduced the viability of all cancer cells we tested. Our findings suggest that AgNPs-PTX may be an anticancer agent candidate that is more effective than PTX alone and specific to Saos-2 cells.
dc.identifier.doi10.1016/j.jddst.2020.102265
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85097741641
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2020.102265
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29881
dc.identifier.volume61
dc.identifier.wosWOS:000619160500005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Drug Delivery Science and Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSilver nanoparticles
dc.subjectCytotoxicity
dc.subjectPaclitaxel
dc.subjectCancer cell lines
dc.subjectSaos-2
dc.titleSelective cytotoxicity of paclitaxel bonded silver nanoparticle on different cancer cells
dc.typeArticle

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