Predictive value of pregnancy of follicular fluid fetuin-A and -B levels in infertile women after intra-cytoplasmic sperm injection

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dc.authoridYURTCU, NAZAN/0000-0003-4725-043X
dc.authoridoral, serkan/0000-0002-1311-6278
dc.authoridALAGOZ, MURAT/0000-0002-6744-1754
dc.contributor.authorYurtcu, Nazan
dc.contributor.authorOral, Serkan
dc.contributor.authorCelik, Sebahattin
dc.contributor.authorCaliskan, Suleyman Tumer
dc.contributor.authorAlagoz, Murat
dc.contributor.authorDahan, Michael H.
dc.date.accessioned2024-10-26T18:11:17Z
dc.date.available2024-10-26T18:11:17Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractAim We aimed to investigate the value of follicular fluid fetuins-A and -B to predict successful IVF and pregnancy outcomes in infertile women with poor, normal, and high ovarian reserve. Methods The follicular fluid of 96 infertile women who underwent intra-cytoplasmic sperm injection (ICSI) procedure was analyzed. Fetuins-A and -B levels were examined and compared in those who could achieve pregnancy and those who could not. Receiver operating characteristic curve analyzes were used to determine cut-off and statistically significant associations for fetuins-A and -B. Results Follicular fluid fetuin-A levels were higher in cases with weak ovarian reserve (OR) (p < 0.05) and higher in patients who did not achieve clinical pregnancy (p < 0.05). Conversely, the follicular fluid fetuin-B levels were lower in cases with poor OR (p < 0.05) and were lower in patients who did not achieve a clinical pregnancy (p < 0.05). A follicular fluid fetuin-A concentration <= 19.12 ng/mL had a sensitivity and specificity of 94.74% and 93.1%, respectively, at predicting clinical pregnancy. While the follicular fluid fetuin-B concentration >24.7 ng/mL had sensitivity and specificity of 71.1% and 51.7%, respectively, for clinical pregnancy prediction. Conclusion Overall, high levels of follicular fluid fetuin-A may be independently associated with unsuccessful IVF irrespective of OR grouping. A low level of follicular fetuin-B was also associated with failed IVF. The sensitivity and specificity were found to be higher for fetuin-A in predicting clinical pregnancy. Therefore, the follicular fluid fetuin-A may be more predictive for successful IVF and clinical pregnancy outcomes than follicular fluid fetuin-B.
dc.identifier.doi10.1111/jog.15070
dc.identifier.endpage187
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue1
dc.identifier.pmid34708901
dc.identifier.scopus2-s2.0-85117905517
dc.identifier.scopusqualityQ2
dc.identifier.startpage178
dc.identifier.urihttps://doi.org/10.1111/jog.15070
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30594
dc.identifier.volume48
dc.identifier.wosWOS:000711838600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Obstetrics and Gynaecology Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectfetuin-A
dc.subjectfetuin-B
dc.subjectfollicular fluid
dc.subjectICSI
dc.subjectinfertility
dc.subjectIVF
dc.subjectovarian stimulation
dc.subjectpregnancy
dc.titlePredictive value of pregnancy of follicular fluid fetuin-A and -B levels in infertile women after intra-cytoplasmic sperm injection
dc.typeArticle

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