Effect of Topically Applied Minoxidil on the Survival of Rat Dorsal Skin Flap

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dc.authoridGumus, Nazim -- 0000-0002-2422-6456en_US
dc.contributor.authorGumus, Nazim
dc.contributor.authorOdemis, Yusuf
dc.contributor.authorYilmaz, Sarper
dc.contributor.authorTuncer, Ersin
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:03:15Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:03:15Z
dc.date.issued2012
dc.department[Gumus, Nazim -- Odemis, Yusuf -- Yilmaz, Sarper -- Tuncer, Ersin] Cumhuriyet Univ, Fac Med, Dept Plast Reconstruct & Aesthet Surg, Sivas, Turkeyen_US
dc.description.abstractFlap necrosis still is a challenging problem in reconstructive surgery that results in irreversible tissue loss. This study evaluated the effect of topically applied minoxidil on angiogenesis and survival of a caudally based dorsal rat skin flap. For this study, 24 male Wistar rats were randomly divided into three groups of eight each. A caudally based dorsal skin flap with the dimensions of 9 x 3 cm was raised. After elevation of the flaps, they were sutured back into their initial positions. In group 1 (control group), 1 ml of isotonic saline was applied topically to the flaps of all the animals for 14 days. In group 2, minoxidil solution was spread uniformly over the flap surface for 7 days after the flap elevation. In group 3, minoxidil solution was applied topically to the flap surface during a 14-day period. On day 7 after the flap elevation, the rats were killed. The average area of flap survival was determined for each rat. Subdermal vascular architecture and angiogenesis were evaluated under a light microscope after two full-thickness skin biopsy specimens had been obtained from the midline of the flaps. The lowest flap survival rate was observed in group 1, and no difference was observed between groups 1 and 2. Compared with groups 1 and 2, group 3 had a significantly increased percentage of flap survival (P < 0.05). Intense and moderate angiogenesis also was observed respectively at the proximal and distal areas of the flaps in group 3. The results of this experiment seem to show that the early effect of minoxidil is vasodilation and that prolonged use before flap elevation leads to angiogenesis, increasing flap viability. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.en_US
dc.identifier.doi10.1007/s00266-012-9966-2en_US
dc.identifier.endpage1386en_US
dc.identifier.issn0364-216X
dc.identifier.issue6en_US
dc.identifier.pmid22955791en_US
dc.identifier.scopus2-s2.0-84877587072en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage1382en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00266-012-9966-2
dc.identifier.urihttps://hdl.handle.net/20.500.12418/8945
dc.identifier.volume36en_US
dc.identifier.wosWOS:000312070000017en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofAESTHETIC PLASTIC SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiogenesisen_US
dc.subjectFlap survivalen_US
dc.subjectMinoxidilen_US
dc.subjectTopical applicationen_US
dc.titleEffect of Topically Applied Minoxidil on the Survival of Rat Dorsal Skin Flapen_US
dc.typeArticleen_US

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