The effect of taxifolin on oxidative ovarian damage and reproductive dysfunctions induced by antipsychotic drugs in female rats

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dc.authoridgezer, arzu/0000-0002-1658-2098
dc.authoridKuzucu, Mehmet/0000-0002-7786-7687
dc.authoridCetin, Nihal/0000-0003-3233-8009
dc.contributor.authorInce, Sefa
dc.contributor.authorOzer, Mehmet
dc.contributor.authorKadioglu, Berrin Goktug
dc.contributor.authorKuzucu, Mehmet
dc.contributor.authorOzkaraca, Mustafa
dc.contributor.authorGezer, Arzu
dc.contributor.authorSuleyman, Halis
dc.date.accessioned2024-10-26T18:11:19Z
dc.date.available2024-10-26T18:11:19Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractAim Typical antipsychotics (TAPs) are commonly used to treat schizophrenia and bipolar disorder. However, extrapyramidal disorders, hyperprolactinemia, and reproductive dysfunctions have been observed in women during the use of TAPs. For this reason, less toxic and prolactin-sparing atypical antipsychotic (AAP) drugs such as clozapine (CLN) have been developed. The aim of this study is to investigate the effect of taxifolin on possible ovarian and reproductive toxicity associated with CLN and haloperidol (HPL) in female Wistar albino rats. Methods The rats were grouped as healthy control group (HCG), CLN, HPL, taxifolin + clozapine (TCL), and taxifolin + haloperidol (THL). Drugs were administered to the groups for 28 days. At the end of that time, ovarian tissues of six rats from each group were taken for histopathological and biochemical analyses. Remaining six rats in groups were examined for evaluation of reproductive dysfunctions. Results Severe degeneration and vacuolization were observed in the primary, secondary, and primordial follicles of the ovarian tissues of CLN- and HPL-treated groups, of which malondialdehyde (MDA) level was high and total glutathione (tGSH) level was low. In the taxifolin-treated groups, taxifolin significantly prevented the increase of MDA level and decrease of tGSH level, and the severity of histopathological damage was found to be lower. In addition, it was found that taxifolin significantly prevented infertility and delay in pregnancy associated with CLN and HPL. Conclusions The results of this experiment suggest that taxifolin can be beneficial in treating oxidative ovarian damage, infertility, and reproductive dysfunctions induced by CLN and HPL.
dc.identifier.doi10.1111/jog.14769
dc.identifier.endpage2148
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue6
dc.identifier.pmid33754437
dc.identifier.scopus2-s2.0-85102895313
dc.identifier.scopusqualityQ2
dc.identifier.startpage2140
dc.identifier.urihttps://doi.org/10.1111/jog.14769
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30620
dc.identifier.volume47
dc.identifier.wosWOS:000631346300001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Obstetrics and Gynaecology Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectantioxidant activity
dc.subjectclozapine
dc.subjecthaloperidol
dc.subjectpregnancy
dc.subjecttaxifolin
dc.titleThe effect of taxifolin on oxidative ovarian damage and reproductive dysfunctions induced by antipsychotic drugs in female rats
dc.typeArticle

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