Evaluation of quality of life in patients with gastric adenocarcinoma receiving chemoradiotherapy: a cross-sectional study

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dc.authoridYILMAZ, MUKADDES/0000-0002-7927-8480
dc.authoridUCAR, MAHMUT/0000-0002-3311-6152
dc.authoridYucel, Birsen/0000-0002-0083-6866
dc.authoriderdis, eda/0000-0003-3003-8643
dc.contributor.authorYilmaz, Mukaddes
dc.contributor.authorErdis, Eda
dc.contributor.authorUcar, Mahmut
dc.contributor.authorYucel, Birsen
dc.date.accessioned2024-10-26T18:04:00Z
dc.date.available2024-10-26T18:04:00Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractPurposeThe aim of this study was to evaluate quality of life (QoL) in patients with gastric adenocarcinoma receiving adjuvant chemoradiotherapy (CRT).MethodsThe European Organization for Cancer Research and Treatment Quality of Life Questionnaire-Core 30 (QLQ-C30) and site-specific module for gastric cancer (QLQ-STO22) were administered at four time points to 156 patients admitted to Cumhuriyet University Oncology Center between 2011 and 2018.ResultsThe patient group comprised 76% men and 24% women with a median age of 61 years (range, 18-88). During CRT, 12 patients (8%) discontinued treatment, 25 (16%) lost weight, and 42 (27%) had reduced performance. There was significant worsening in QLQ-C30 global health status and all functional and symptom scale scores at CRT completion. These changes were also clinically significant except for physical functioning scores and were supported by minimal clinically important difference measurements. In the QLQ-STO22, all symptoms except dry mouth and hair loss were negatively affected at CRT completion. In general, scores were improved at 1 month after CRT and almost all scores reached baseline level by 6 months. Certain scores were more adversely affected in women (global health status, physical functioning, role functioning, fatigue, pain, and insomnia), those who lost weight during CRT (emotional functioning), and those with CRT interruption (emotional functioning and anxiety).ConclusionAlthough CRT reduces QoL in patients with gastric cancer, the effects tend to resolve within 6 months after completing treatment. Female sex, weight loss, and CRT interruption negatively affected some QoL scores.
dc.identifier.doi10.1007/s00520-023-08036-3
dc.identifier.issn0941-4355
dc.identifier.issn1433-7339
dc.identifier.issue10
dc.identifier.pmid37770678
dc.identifier.scopus2-s2.0-85172825935
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s00520-023-08036-3
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28686
dc.identifier.volume31
dc.identifier.wosWOS:001082277700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofSupportive Care in Cancer
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGastric Cancer
dc.subjectChemoradiotherapy
dc.subjectQuality of Life
dc.subjectEORTC QLQ-C30
dc.subjectEORTC QLQ-STO22
dc.titleEvaluation of quality of life in patients with gastric adenocarcinoma receiving chemoradiotherapy: a cross-sectional study
dc.typeArticle

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