Determination of Selected Phthalates in Some Commercial Cosmetic Products by HPLC-UV

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dc.authoridDural, Emrah/0000-0002-9320-8008
dc.contributor.authorDural, Emrah
dc.date.accessioned2024-10-26T18:02:26Z
dc.date.available2024-10-26T18:02:26Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractAim and Scope: Due to the serious toxicological risks and their widespread use, quantitative determination of phthalates in cosmetic products have importance for public health. The aim of this study was to develop a validated simple, rapid and reliable high-performance liquid chromatography (HPLC) method for the determination of phthalates which are; dimethyl phthalate (DMP), diethyl phthalate (DEP), benzyl butyl phthalate (BBP), di-n-butyl phthalate (DBP), di(2-ethylhexyl) phthalate (DEHP), in cosmetic products and to investigate these phthalate (PHT) levels in 48 cosmetic products marketing in Sivas, Turkey. Materials and Methods: Separation was achieved by a reverse-phase ACE-5 C-18 column (4.6 x 250 mm, 5.0 mu m). As the mobile phase, 5 mM KH2PO4 and acetonitrile were used gradiently at 1.5 ml min(-1). All PHT esters were detected at 230 nm and the run time was taking 21 minutes. Results: This method showed the high sensitivity value the limit of quantification (LOQ) values for which are below 0.64 mu g mL(-1) of all phthalates. Method linearity was >= 0.999 (r(2)). Accuracy and precision values of all phthalates were calculated between (-6.5) and 6.6 (RE%) and <= 6.2 (RSD%), respectively. Average recovery was between 94.8% and 99.6%. Forty-eight samples used for both babies and adults were successfully analyzed by the developed method. Results have shown that, DMP (340.7 mu g mL(-1) +/- 323.7), DEP (1852.1 mu g mL(-1) +/- 2192.0), and DBP (691.3 mu g mL(-1) +/- 1378.5) were used highly in nail polish, fragrance and cream products, respectively. Conclusion: Phthalate esters, which are mostly detected in the content of fragrance, cream and nail polish products and our research in general, are DEP (1852.1 mu g mL(-1) +/- 2192.0), DBP (691.3 mu g mL(-1) +/- 1378.5) and DMP (340.7 mu g mL(-1) +/- 323.7), respectively. Phthalates were found in the content of all 48 cosmetic products examined, and the most detected phthalates in general average were DEP (581.7 mu g mL(-1) +/- 1405.2) with a rate of 79.2%. The unexpectedly high phthalate content in the examined cosmetic products revealed a great risk of these products on human health. The developed method is a simple, sensitive, reliable and economical alternative for the determination of phthalates in the content of cosmetic products, it can be used to identify phthalate esters in different products after some modifications.
dc.description.sponsorshipScientific Research Projects Support Programme of Sivas Cumhuriyet University [ECZ-027]
dc.description.sponsorshipThis study was supported by Scientific Research Projects Support Programme of Sivas Cumhuriyet University under the project no. ECZ-027.
dc.identifier.doi10.2174/1386207323666200630113850
dc.identifier.endpage1022
dc.identifier.issn1386-2073
dc.identifier.issn1875-5402
dc.identifier.issue10
dc.identifier.pmid32603277
dc.identifier.scopus2-s2.0-85096658673
dc.identifier.scopusqualityQ3
dc.identifier.startpage1010
dc.identifier.urihttps://doi.org/10.2174/1386207323666200630113850
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28154
dc.identifier.volume23
dc.identifier.wosWOS:000604264700004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCombinatorial Chemistry & High Throughput Screening
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPhthalates
dc.subjectDEP
dc.subjectDMP
dc.subjectBBP
dc.subjectDBP
dc.subjectDEHP
dc.subjectcosmetics
dc.subjectHPLC-UV
dc.subjectmethod validation
dc.titleDetermination of Selected Phthalates in Some Commercial Cosmetic Products by HPLC-UV
dc.typeArticle

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