Design, synthesis and in vitro antiproliferation activity of some 2-aryl and -heteroaryl benzoxazole derivatives

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dc.contributor.authorKuzu, Burak
dc.contributor.authorHEPOKUR, CEYLAN
dc.contributor.authorTürkmenoğlu,Burçin
dc.contributor.authorBurmaoğlu,Serdar
dc.contributor.authorAlgül, öztekin
dc.date.accessioned2023-06-23T05:18:30Z
dc.date.available2023-06-23T05:18:30Z
dc.date.issued2022tr
dc.departmentEczacılık Fakültesitr
dc.description.abstractBackground: Phortress produces reactive electrophilic metabolites that form DNA adducts only in sensitive tumor cells. The authors converted the 2-phenylbenzothiazole nucleus in phortress to 2- aryl and -heteroaryl benzoxazole derivatives (11 new and 14 resynthesized). All synthesized compounds were studied for antitumor activity in various cancer cells. Materials & methods: Cytotoxicity, cell morphology, flow cytometry and cell-cycle analyses of compounds were performed and more active derivatives were tested in the MCF-7 cell line. Conclusion: Methyl 2- (thiophen-2-yl)benzo[d]oxazole-6-carboxylate (BK89) has a higher effect than fluorouracil to induce apoptotic cell death (apoptosis value of 49.44%). Cell-cycle analysis shows that the compounds BK89 and methyl 2-(furan-2-yl)benzo[d]oxazole-6-carboxylate (BK82) can be used as potential cell-cycle blockers by arresting MCF-7 cells in G0/G1 phase at rates of 63% and 85%, respectively.tr
dc.identifier.pmid35703122en_US
dc.identifier.scopus2-s2.0-85133103368en_US
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://hdl.handle.net/20.500.12418/14012
dc.identifier.wosWOS:000810906900001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.publicationcategoryRaportr
dc.rightsinfo:eu-repo/semantics/restrictedAccesstr
dc.titleDesign, synthesis and in vitro antiproliferation activity of some 2-aryl and -heteroaryl benzoxazole derivativesen_US
dc.typeArticleen_US

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