Role of electron transfer between bare electrode and benzoguanamine to fabricate an electrochemical sensor for drugs: Theoretical and electrochemical approach

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dc.contributor.authorGanesh, Pattan-Siddappa
dc.contributor.authorElugoke, Saheed Eluwale
dc.contributor.authorKim, Sang-Youn
dc.contributor.authorKaya, Savas
dc.contributor.authorEbenso, Eno E.
dc.date.accessioned2024-10-26T18:09:25Z
dc.date.available2024-10-26T18:09:25Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractHerein, a poly(benzoguanamine) (BNZ) modified carbon paste electrode (CPE) was applied for the electroanalysis of paracetamol (PA) in PA tablet and human urine. Theoretical evaluation of the quantum chemical parameters of benzoguanamine (BZ) via density functional theory (DFT) calculations show that it is a reactive monomer with a tendency for back bond formation with the bare carbon paste electrode (BCPE). Scanning electron microscopy (SEM) images of BCPE and BNZ modified CPE (BNZ/CPE) show that the BNZ films were deposited on the bare electrode in layers. Results of the electrochemical characterization of these electrodes in 1 mM K4[Fe(CN)6] revealed that the BNZ/CPE has a higher electrocatalytic activity towards K4[Fe(CN)6] oxidation than BCPE. The limit of detection (LOD) of PA at the BNZ/CPE was estimated as 13.2 nM over a linear dynamic range (LDR) of 0.05-0.45 mu M. Also, the proposed sensor offered PA recoveries of 99.2-100.4 % and 98.4-100.8 % in PA tablet solution and human urine sample, respectively. The BNZ/CPE showed remarkable shelf-life by retaining 97.4 % of its initial current response after 21 days of application for PA electroanalysis at 7 days interval. Notably, this study is the first attempt at the application of the BNZ/CPE for PA electroanalysis.
dc.description.sponsorshipNational Research Foundation of Korea (NRF) - Ministry of Education [NRF-2018R1A6A1A03025526]; Ministry of Education and National Research Foundation of Korea
dc.description.sponsorshipThis work was supported by Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2018R1A6A1A03025526) . Following are results of a study on the Leaders in INdustry-university Cooperation 3.0 Project, supported by the Ministry of Education and National Research Foundation of Korea. Authors also acknowledge the Cooperative Equipment Center at KoreaTech for technical discussions and research facilities. SEE acknowledge UNISA for research facilities.
dc.identifier.doi10.1016/j.microc.2024.110731
dc.identifier.issn0026-265X
dc.identifier.issn1095-9149
dc.identifier.scopus2-s2.0-85192730219
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.microc.2024.110731
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30082
dc.identifier.volume201
dc.identifier.wosWOS:001241585300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofMicrochemical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBenzoguanamine
dc.subjectDFT calculation
dc.subjectDifferential pulse voltammetry
dc.subjectElectrochemical sensor
dc.subjectElectrodeposition
dc.titleRole of electron transfer between bare electrode and benzoguanamine to fabricate an electrochemical sensor for drugs: Theoretical and electrochemical approach
dc.typeArticle

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