Effects of intravenous anesthetics on the human radial artery used as a coronary artery bypass graft

Basit Öğe Kaydı
dc.contributor.authorGursoy, Sinan
dc.contributor.authorBerkan, Ocal
dc.contributor.authorBagcivan, Ihsan
dc.contributor.authorKaya, Tijen
dc.contributor.authorYildirim, Kemal
dc.contributor.authorMimaroglu, Caner
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:17:01Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:17:01Z
dc.date.issued2007
dc.departmentCumhuriyet Univ, Sch Med, Dept Pharm, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Cardiothorac Surg, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkeyen_US
dc.description.abstractObjective: Intravenous anesthetics are often used for anesthesia, sedation, and analgesia in the intraoperative and postoperative periods of coronary artery bypass graft (CABG) surgery. This study was designed to investigate the direct effects of intravenous anesthetics on the human radial artery (RA). Design: In vitro, prospective with repeated measures. Setting: University research laboratory. Participants: RA segments (n = 20) were obtained from CABG surgery patients and were divided into 3- to 4-mm vascular rings. Interventions: Using the organ bath technique, the endothelium-independent vasodilatation function was tested in vitro by the addition of cumulative concentrations of thiopental, ketamine, etomidate, and propofol after vasocontraction by phenylephrine in the presence of NG-nitro-L-arginine methyl ester (L-NAME) and indomethacin. Measurements and Main Results: Thiopental (10(-8) to 10(-4) mol/L), ketamine(10(-8) to 10(-4) mol/L), propofol (10(-8) to 3 x 10-(4) mol/L), and etomidate (10(-8) to 3 x 10(-4) mol/L) caused concentration-dependent vasorelaxation in human RA rings precontracted with phenylephrine in the presence of L-NAME and indomethacin (n = 20, for each drug). The pEC(50) and maximum relaxant effect values of thiopental and ketamine were significantly higher than for etomidate and propofol (p < 0.05). Conclusions: These findings indicate that thiopental, ketamine, etomidate, and propofol produce concentration-dependent relaxation on RA rings from humans. Thiopental and ketamine are more potent relaxant agents than etomidate and propofol. Intravenous anesthetics may be effective as alternative vasodilators for treatment of intraoperative and postoperative spasm of coronary artery grafts. (c) 2007 Elsevier Inc. All rights reserveden_US
dc.identifier.doi10.1053/j.jvca.2005.11.021en_US
dc.identifier.endpage44en_US
dc.identifier.issn1053-0770
dc.identifier.issn1532-8422
dc.identifier.issue1en_US
dc.identifier.pmid17289478en_US
dc.identifier.scopus2-s2.0-33846686492en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage41en_US
dc.identifier.urihttps://dx.doi.org/10.1053/j.jvca.2005.11.021
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10667
dc.identifier.volume21en_US
dc.identifier.wosWOS:000244804600008en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B SAUNDERS CO-ELSEVIER INCen_US
dc.relation.ispartofJOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectradial arteryen_US
dc.subjectintravenous anestheticsen_US
dc.subjectvasorelaxationen_US
dc.titleEffects of intravenous anesthetics on the human radial artery used as a coronary artery bypass graften_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksyonu
Scopus İndeksli Yayınlar Koleksiyonu