Evaluation of the Effect of Gabapentin on Tendon Healing in an Experimental Rat Model

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dc.contributor.authorKilinc, Seyran
dc.contributor.authorEgilmez, Hatice Reyhan
dc.contributor.authorPazarci, Ozhan
dc.contributor.authorAltunisik, Muhammed Yasir
dc.date.accessioned2024-10-26T18:00:17Z
dc.date.available2024-10-26T18:00:17Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBACKGROUND/AIMS To investigate the effect of gabapentin used in postoperative pain prophylaxis on tendon healing. MATERIAL and METHODS A total of 32 Wistar albino rats were randomly divided into 4 groups. Groups A and C were administered gabapentin by oral gavage, while Groups B and D were defined as the control groups. In all the rats, a transverse cut was made on the left Achilles tendon, approximately 0.5 cm proximal to the attachment point of the bone, then it was sutured using the Kessler method. Rats in Groups A and B were sacrificed on day 15 and those in Groups C and D on day 45. Differences between the groups were evaluated biomechanically using the tensile test, and immunohistochemically by examinations of collagen type 1 (COL1A), Proliferating Cell Nuclear Antigen (PCNA), and Transforming Growth Factor beta 1 (TGF-beta 1). RESULTS In the biomechanical evaluations, no significant difference was found between the study and control groups on days 15 and 45 in terms of the tensile test results (day 15, p=0.908; day 45, p=0.798). In the semi-quantitative comparisons of positive cell involvement in the immunohistochemical data evaluations, no statistically significant difference was also found. [TGF-beta 1, p(15)=0.328, p(45)=0.195; PCNA p(15)=0.645]. PCNA-positive cells were seen at a high rate in the first 15 days in both groups and the involvement of these cells was found to be similar on day 45. CONCLUSION In the immunohistochemical and biomechanical evaluations, gabapentin was not found to have any negative effect on tendon healing. It can be concluded that gabapentin can be used in cases with appropriate indications after tendon surgery. Nevertheless, there is a need for further studies in this area to investigate the mechanism of gabapentin's effect on the tendon.
dc.description.sponsorshipScientific Research Project Fund of Cumhuriyet university [T-763]
dc.description.sponsorshipThis work was supported by the Scientific Research Project Fund of Cumhuriyet university under project number T-763.
dc.identifier.doi10.5152/cjms.2020.1968
dc.identifier.endpage244
dc.identifier.issn2149-7893
dc.identifier.issn2536-507X
dc.identifier.issue3
dc.identifier.startpage239
dc.identifier.trdizinid419644
dc.identifier.urihttps://doi.org/10.5152/cjms.2020.1968
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/419644
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27610
dc.identifier.volume5
dc.identifier.wosWOS:000576796500010
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAves
dc.relation.ispartofCyprus Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGabapentin
dc.subjecttendon healing
dc.subjectexperimental study
dc.titleEvaluation of the Effect of Gabapentin on Tendon Healing in an Experimental Rat Model
dc.typeArticle

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