Role of mean platelet volume in triagging acute coronary syndromes

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dc.authoridYILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628; YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628en_US
dc.contributor.authorYilmaz, Mehmet Birhan
dc.contributor.authorCihan, Gokhan
dc.contributor.authorGuray, Yesim
dc.contributor.authorGuray, Umit
dc.contributor.authorKisacik, Halil L.
dc.contributor.authorSasmaz, Hatice
dc.contributor.authorKorkmaz, Sule
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:15:07Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:15:07Z
dc.date.issued2008
dc.department[Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Sch Med, Dept Cardiol, Sivas, Turkey -- [Cihan, Gokhan -- Guray, Yesim -- Guray, Umit -- Kisacik, Halil L. -- Sasmaz, Hatice -- Korkmaz, Sule] Yuksek Ihtisas Hosp, Cardiol Clin, Ankara, Turkeyen_US
dc.description.abstractBackground: Acute coronary syndromes, characterized by the rupture of unstable plaque and the subsequent thrombotic process involving platelets, have been increasing in relative frequency. The central role of platelet activation has long been noticed in this pathophysiology; hence, many therapies have been directed against it. In this study, we have aimed to search prospectively the value of mean platelet volume (MPV), which is a simple and accurate measure of the functional status of platelets, in patients hospitalized with diagnosis of acute coronary syndromes (ACS). Materials and methods: A total of 216 consecutive patients (156 male, 60 female) hospitalized with the diagnosis of non-ST segment elevation (NSTE) ACS within the first 24 h of their chest pain were enrolled. One hundred and twenty patients, matched according to sex and age, with stable coronary heart disease (CHD) (85 male, 35 female) were enrolled as a control group. Patients were classified into two group: those with unstable angina (USAP, n = 105) and those with non-ST segment elevation myocardial infarction (NSTEMI, n = 111). Results: MPVs were 10.4 +/- 0.6 fL, 10 +/- 0.7 fL, 8.9 +/- 0.7 fL consecutively for NSTEMI, USAP and stable CHD with significant differences. Patients with ischemic attacks in the first day of hospitalization accompanied by > 0.05 mV ST segment shift had significantly higher MPV compared to those without such attacks (P = 0.001). Multivariable logistic regression analysis yielded that MPV (P = 0.016), platelet count (P < 0.001), and the presence of > 0.05 mV ST segment depression at admission (P = 0.002) were independent predictors of development of NSTEMI in patients presenting with NSTE ACS. Conclusion: In patients presenting with NSTE ACS, higher MPV, though there are overlaps among subgroups, indicates not only more risk of having NSTEMI but also ischemic complications.en_US
dc.identifier.doi10.1007/s11239-007-0078-9en_US
dc.identifier.endpage54en_US
dc.identifier.issn0929-5305
dc.identifier.issn1573-742X
dc.identifier.issue1en_US
dc.identifier.pmid17705053en_US
dc.identifier.scopus2-s2.0-48549092701en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage49en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s11239-007-0078-9
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10341
dc.identifier.volume26en_US
dc.identifier.wosWOS:000257946700009en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofJOURNAL OF THROMBOSIS AND THROMBOLYSISen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmean platelet volumeen_US
dc.subjectacute coronary syndromesen_US
dc.subjectplateletsen_US
dc.titleRole of mean platelet volume in triagging acute coronary syndromesen_US
dc.typeArticleen_US

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