Can We Predict the Sites of the Recurrence of Ovarian Cancer by F-18 FDG PET/CT Depending on CA-125 Level?

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dc.authoridCIFTCI, ESRA -- 0000-0001-6106-7733en_US
dc.contributor.authorTurgut, Bulent
dc.contributor.authorCiftci, Esra
dc.contributor.authorErturk, Seyit Ahmet
dc.contributor.authorCetin, Bulent
dc.contributor.authorAker, Handan
dc.contributor.authorHasbek, Zekiye
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:44:10Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:44:10Z
dc.date.issued2017
dc.department[Turgut, Bulent -- Ciftci, Esra -- Erturk, Seyit Ahmet -- Hasbek, Zekiye] Cumhuriyet Univ, Sch Med, Dept Nucl Med, PK 848,Campus Sivas, TR-58140 Sivas, Turkey -- [Cetin, Bulent] Recep Tayyip Erdogan Univ, Sch Med, Div Med Oncol, Dept Internal Med, Rize, Turkey -- [Aker, Handan] Cumhuriyet Univ, Sch Med, Dept Pathol, Sivas, Turkeyen_US
dc.description.abstractObjectives: The purpose of the study is predicting the sites of the recurrence with PET/CT by serum CA-125 level and detecting the cut-off value of CA-125 for metastatic ovarian cancer (OC) in comparison with Fluorine-18 FDG PET/CT. Materials & Methods: For 38 patients with histological stage III-IV OC, F-18 FDG PET/CT studies (n=59) referred for suspicion of relapsing of OC were conducted. PET/CT images were assessed as positive/negative in 4 categories based on similar location as local recurrence, peritoneal metastasis, lymph node metastases and distant metastases. Patients were divided into five groups according to the levels of CA-125. The results of PET/CT imaging were compared with the level of CA-125. Results: Recurrence was confirmed in all FDG-PET/CT studies. In 7 of them (11.9%) CA-125 levels were normal (mean: 18.9 +/- 5.9) whereas in 52 of them (88%) were high (mean: 433.9 +/- 798.3). Moderate but highly significant positive correlation between CA-125 level and the number of metastatic foci detected by PET/CT was found. There was no statistically significant difference between CA-125 level subgroups and metastatic sites. However, the difference between CA-125 levels and location of metastasis was statistically significant only for distant metastasis and peritoneal metastasis with moderate accuracy (71% and %66, respectively). Conclusion: Since CA-125 has moderate but highly significant positive correlation with the number of metastatic foci, it is important in clinical management of OC patients. However, it may not predict the localization of the recurrence. When suspicious findings were reported at radiodiagnostic techniques in OC patients, FDG-PET is a useful technique for detecting recurrent ovarian carcer regardless of CA-125 level.en_US
dc.identifier.doi10.2174/1573405613666170823154759en_US
dc.identifier.endpage437en_US
dc.identifier.issn1573-4056
dc.identifier.issn1875-6603
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85051633157en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage431en_US
dc.identifier.urihttps://dx.doi.org/10.2174/1573405613666170823154759
dc.identifier.urihttps://hdl.handle.net/20.500.12418/6949
dc.identifier.volume13en_US
dc.identifier.wosWOS:000415813000009en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBENTHAM SCIENCE PUBL LTDen_US
dc.relation.ispartofCURRENT MEDICAL IMAGING REVIEWSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSerum CA-125en_US
dc.subjectmetastatic ovarian cancer (OC)en_US
dc.subjectfluorine-18 FDG PET/CTen_US
dc.subjectperitoneal metastasisen_US
dc.subjectlymph node metastasesen_US
dc.subjectdistant metastasesen_US
dc.titleCan We Predict the Sites of the Recurrence of Ovarian Cancer by F-18 FDG PET/CT Depending on CA-125 Level?en_US
dc.typeArticleen_US

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