The Usefulness of Monocyte-to-High Density Lipoprotein and Neutrophil-to-Lymphocyte Ratio in Diabetic Macular Edema Prediction and Early anti-VEGF Treatment Response

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dc.authoridBozali, Erman/0000-0001-7918-8381
dc.authoridErdogan, Haydar/0000-0002-9337-6968
dc.authoridYalinbas, Duygu/0000-0001-9001-0277
dc.contributor.authorYeter, Duygu Yalinbas
dc.contributor.authorEroglu, Serap
dc.contributor.authorSariakcali, Baris
dc.contributor.authorBozali, Erman
dc.contributor.authorOzec, Ayse Vural
dc.contributor.authorErdogan, Haydar
dc.date.accessioned2024-10-26T18:04:18Z
dc.date.available2024-10-26T18:04:18Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractPurpose: To determine the association of monocyte-to-high-density lipoprotein ratio (MHR) and neutrophil-to-lymphocyte ratio (NLR) with diabetic macular edema (DME) and early anti-VEGF treatment response. Material methods: This was a retrospective and cross-sectional study conducted with 143 patients with diabetes mellitus (53 diabetic retinopathy with DME, 38 diabetic retinopathy without DME, and 52 without diabetic retinopathy). Results: 13.9 was the best cutoff value to predict DME for MHR, and 2 was for NLR (59% and 75% sensitivity and 81% and 59% specificity, respectively). Logistic regression analysis showed that NLR >= 2 and MHR >= 13.9 were significantly associated with DME prediction. However, neither NLR >= 2 nor MHR >= 13.9 was associated with central retinal thickness(CRT) or best corrected visual acuity(BCVA) outcomes after anti-VEGF treatment. On the other hand, increased NLR was associated with inferior CRT outcomes. Conclusion: MHR and NLR were simple and cost-effective biomarkers to predict DME. Moreover, higher NLR may contribute to poor CRT outcomes.
dc.identifier.doi10.1080/09273948.2020.1849739
dc.identifier.endpage906
dc.identifier.issn0927-3948
dc.identifier.issn1744-5078
dc.identifier.issue4
dc.identifier.pmid33596398
dc.identifier.scopus2-s2.0-85101043463
dc.identifier.scopusqualityQ1
dc.identifier.startpage901
dc.identifier.urihttps://doi.org/10.1080/09273948.2020.1849739
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28861
dc.identifier.volume30
dc.identifier.wosWOS:000619052100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofOcular Immunology and Inflammation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDiabetes
dc.subjectmacular edema
dc.subjectretinopathy
dc.subjectinflammation
dc.subjectmonocyte
dc.subjecthigh-density lipoprotein
dc.titleThe Usefulness of Monocyte-to-High Density Lipoprotein and Neutrophil-to-Lymphocyte Ratio in Diabetic Macular Edema Prediction and Early anti-VEGF Treatment Response
dc.typeArticle

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