Ghrelin receptor agonist hexarelin attenuates antinociceptive tolerance to morphine in rats

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dc.authoridTaskiran, Ahmet Sevki/0000-0002-5810-8415
dc.authoridOzdemir, Ercan/0000-0001-8231-1053
dc.contributor.authorBaser, Tayfun
dc.contributor.authorOzdemir, Ercan
dc.contributor.authorFiliz, Ahmet Kemal
dc.contributor.authorTaskiran, Ahmet Sevki
dc.contributor.authorGursoy, Sinan
dc.date.accessioned2024-10-26T18:03:51Z
dc.date.available2024-10-26T18:03:51Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractGhrelin, a peptide hormone released from the gastric endocrine glands, shows analgesic activity apart from its various physiological effects. Nevertheless, the effects of ghrelin receptor (GHS-R) agonists on morphine analgesia and tolerance have not yet been elucidated. The purpose of this study was to evaluate the effects of the ghrelin receptor agonist hexarelin and antagonist [D-Lys3]-GHRP-6 on morphine antinociception and tolerance in rats. A total of 104 Wistar albino male adult rats (weighing approximately 220-240 g) were used in the experiments. To induce morphine tolerance, a three-day cumulative dose regimen was used in the rats. Then, randomly selected rats were evaluated for morphine tolerance on day 4. The analgesic effects of hexarelin (0.2 mg.kg(-1)), [D-Lys3]-GHRP-6 (10 mg.kg(-1)), and morphine (5 mg.kg(-1)) were measured at 30-min intervals (0, 30, 60, 90, and 120 min) by tail-flick and hot-plate analgesia tests. The findings suggest that hexarelin in combination with morphine attenuates analgesic tolerance to morphine. On the other hand, ghrelin receptor antagonist [D-Lys3]-GHRP-6 has no significant analgesic activity on the morphine tolerance in analgesia tests. Furthermore, co-administration of hexarelin and morphine increases the analgesic effect. In condusion, these data indicate that administration of GHS-R agonist hexarelin with morphine enhances the antinociception and attenuates morphine tolerance.
dc.description.sponsorshipCumhuriyet University Scientific Research Project (CUBAP, Sivas, Turkey) [T-707]
dc.description.sponsorshipThis study was supported by the Cumhuriyet University Scientific Research Project (T-707, CUBAP, Sivas, Turkey). T.B. designed and completed most of the experiments and analyzed the related data. E.O. designed the study, wrote the manuscript, and analyzed the related data. A.K.F. designed the study and revised in manuscript writing. A.S.T. designed and completed most of the experiments. S.G. designed and provided some research materials.
dc.identifier.doi10.1139/cjpp-2020-0218
dc.identifier.endpage467
dc.identifier.issn0008-4212
dc.identifier.issn1205-7541
dc.identifier.issue5
dc.identifier.pmid32893668
dc.identifier.scopus2-s2.0-85105393093
dc.identifier.scopusqualityQ3
dc.identifier.startpage461
dc.identifier.urihttps://doi.org/10.1139/cjpp-2020-0218
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28619
dc.identifier.volume99
dc.identifier.wosWOS:000651646200002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCanadian Science Publishing
dc.relation.ispartofCanadian Journal of Physiology and Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectopioid
dc.subjectghrelin receptors
dc.subjecthexarelin
dc.subjectGHRP-6
dc.subjectmorphine tolerance
dc.titleGhrelin receptor agonist hexarelin attenuates antinociceptive tolerance to morphine in rats
dc.typeArticle

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