Association Between ApoE4 Allele and Deep Venous Thrombosis: A Pilot Study

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dc.authoridYILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628en_US
dc.contributor.authorKatrancioglu, Nurkay
dc.contributor.authorManduz, Sinasi
dc.contributor.authorOzen, Filiz
dc.contributor.authorYilmaz, Mehmet Birhan
dc.contributor.authorAtahan, Erhan
dc.contributor.authorOzdemir, Ozturk
dc.contributor.authorBerkan, Ocal
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:05:47Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:05:47Z
dc.date.issued2011
dc.department[Katrancioglu, Nurkay -- Manduz, Sinasi -- Atahan, Erhan -- Berkan, Ocal] Cumhuriyet Univ, Dept Cardiovasc Surg, Sch Med, TR-58140 Sivas, Turkey -- [Ozen, Filiz -- Ozdemir, Ozturk] Cumhuriyet Univ, Dept Med Biol & Genet, Sch Med, TR-58140 Sivas, Turkey -- [Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Dept Cardiol, Sch Med, TR-58140 Sivas, Turkeyen_US
dc.description.abstractMaterials and Methods: We aimed to search the relative frequencies ApoE alleles among patients with DVT and healthy participants. We enrolled 59 consecutive patients with DVT and 59 age- and sex-matched healthy controls. Results: In the DVT group, E3/E4 gene polymorphism was detected in 20 patients (33.9%), in the control group E3/E4 polymorphism was detected in six patients (10.2%; P = .002). In the multivariable regression analysis, E3/E4 was independently associated with 1.31-fold increased risk of DVT (odds ratio [OR] 1.31; 95% confidence interval [CI], 1.30-10.48). Conclusion: It seems there is a relationship between ApoE3/E4 gene polymorphism and DVT in the Turkish population. However, this pilot study should be supported with large-scale studies.en_US
dc.identifier.doi10.1177/1076029609348646en_US
dc.identifier.endpage228en_US
dc.identifier.issn1076-0296
dc.identifier.issn1938-2723
dc.identifier.issue2en_US
dc.identifier.pmid19825914en_US
dc.identifier.scopus2-s2.0-79952795345en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage225en_US
dc.identifier.urihttps://dx.doi.org/10.1177/1076029609348646
dc.identifier.urihttps://hdl.handle.net/20.500.12418/9574
dc.identifier.volume17en_US
dc.identifier.wosWOS:000288463500016en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS INCen_US
dc.relation.ispartofCLINICAL AND APPLIED THROMBOSIS-HEMOSTASISen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectdeep venous thrombosisen_US
dc.subjectApolipoproteinen_US
dc.subjectE3/E4en_US
dc.subjectgene polymorphismen_US
dc.titleAssociation Between ApoE4 Allele and Deep Venous Thrombosis: A Pilot Studyen_US
dc.typeArticleen_US

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