Effects of Alendronate on Kidney Tissue of Ovariectomized Rats

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dc.contributor.authorCevik, Ozge
dc.contributor.authorArslan, Ahmet Hamdi
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:59:01Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:59:01Z
dc.date.issued2013
dc.department[Cevik, Ozge] Cumhuriyet Univ, Eczacilik Fak, Biyokimya Anabilim Dali, TR-58140 Sivas, Turkey -- [Arslan, Ahmet Hamdi] Yeditepe Univ, Dis Hekimligi Fak, Agiz Cene Cerrahisi Anabilim Dali, TR-34728 Istanbul, Turkeyen_US
dc.description.abstractAlendronate is an aminophosphanate, selective inhibitory of bone resorbtion, used for treatment of osteoporosis in postmenopause. It is known that changes occurring in postmenopausal period effect the quality of life. In this study, effect of the alendronate treatment time on renal oxidative status was investigated in ovariectomized rats. Alendronate was intravenous administered at 0.3 mg/kg dosage on weeks 2, 4 and 8. Serum creatinine and uric acid levels and kidney malondialdehyde (MDA), glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and myeloperoxidase (MPO) level and activities were measured. Serum creatinine and uric acid levels increased in depending on the time of alendronate treatment on ovariectomized rats. Kidney MDA level and MPO activity increased in both ovariectomized and alendronate groups. Kidney GSH level and SOD and CAT activities decreased in the ovariectomized rats and these levels increased in depending on time of alendronate treatment. As a result, some oxidative changes occurred in the kidney tissue of ovariectomized rats with bone resorption and alendronate treatment increased the antioxidant capacity in depending on the time.en_US
dc.identifier.doi10.9775/kvfd.2013.8759en_US
dc.identifier.endpage772en_US
dc.identifier.issn1300-6045
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-84880938404en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage767en_US
dc.identifier.urihttps://dx.doi.org/10.9775/kvfd.2013.8759
dc.identifier.urihttps://hdl.handle.net/20.500.12418/8590
dc.identifier.volume19en_US
dc.identifier.wosWOS:000328082700006en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherKAFKAS UNIV, VETERINER FAKULTESI DERGISIen_US
dc.relation.ispartofKAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlendronateen_US
dc.subjectOxidative stressen_US
dc.subjectOvariectomyen_US
dc.subjectBiphosphanateen_US
dc.titleEffects of Alendronate on Kidney Tissue of Ovariectomized Ratsen_US
dc.typeArticleen_US

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