In vitro evaluation of nebivolol effects on nonadrenergic noncholinergic responses in rabbit corpus cavernosum

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dc.contributor.authorAydin, Kaya
dc.contributor.authorGokcen, Kaan
dc.contributor.authorYildirim, Sahin
dc.contributor.authorBagcivan, Ihsan
dc.contributor.authorParlak, Mesut
dc.contributor.authorGokce, Goekhan
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:37:40Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:37:40Z
dc.date.issued2018
dc.department[Aydin, Kaya -- Yildirim, Sahin -- Bagcivan, Ihsan -- Parlak, Mesut] Cumhuriyet Univ, Sch Med, Dept Pharmacol, Sivas, Turkey -- [Gokcen, Kaan -- Gokce, Goekhan] Cumhuriyet Univ, Sch Med, Dept Urol, Sivas, Turkeyen_US
dc.description.abstractThe purpose of this study was to compare the effects of nebivolol on nonadrenergic noncholinergic (NANC) relaxation functions that are mediated by electric field stimulation (EFS) in rabbit corpus cavernosum smooth muscle by comparison with other beta-adrenergic receptor blockers and show the level on which its effects through nitric oxide take place. After the effects of nebivolol on the isolated corpus cavernosum tissues that were contracted through the alpha-adrenergic pathway and application of L-NAME' (N-G-nitro-L-arginine methyl ester) which is a competitive inhibitor of nitric oxide synthase (NOS), the changes that occurred were recorded. Following the effect on the tissue that was contracted with phenylephrine in the presence of atropine and guanethidine that was created by EFS, nebivolol and other beta-blockers were added and the changes were recorded. After receiving relaxation responses with EFS-mediated NANC, no difference was observed between the relaxation responses due to addition of nebivolol and other beta-adrenergic blockers (p > 0.05). The finding that nebivolol which has a NO-mediated relaxation effect did not have an effect on EFS-mediated NANC relaxation but created relaxation on the tissue that was contracted by phenylephrine and the effect was reversed by L-NAME, shows that its effects are on a postsynaptic level.en_US
dc.identifier.doi10.1111/and.13062en_US
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue8en_US
dc.identifier.pmid29920739en_US
dc.identifier.scopus2-s2.0-85053549659en_US
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1111/and.13062
dc.identifier.urihttps://hdl.handle.net/20.500.12418/6148
dc.identifier.volume50en_US
dc.identifier.wosWOS:000444797600008en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofANDROLOGIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcorpus cavernosumen_US
dc.subjectEFSen_US
dc.subjecterectile dysfunctionen_US
dc.subjectin vitroen_US
dc.subjectnebivololen_US
dc.titleIn vitro evaluation of nebivolol effects on nonadrenergic noncholinergic responses in rabbit corpus cavernosumen_US
dc.typeArticleen_US

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