Effects of Proton Pump Inhibitors and H-2 Receptor Antagonists on the Ileum Motility

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dc.authoridAltun, Ahmet -- 0000-0003-2056-8683en_US
dc.contributor.authorKurt, Atilla
dc.contributor.authorAltun, Ahmet
dc.contributor.authorBagcivan, Ihsan
dc.contributor.authorKoyuncu, Ayhan
dc.contributor.authorTopcu, Omer
dc.contributor.authorAydin, Cengiz
dc.contributor.authorKaya, Tijen
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:06:32Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:06:32Z
dc.date.issued2011
dc.department[Kurt, Atilla -- Koyuncu, Ayhan -- Topcu, Omer -- Aydin, Cengiz] Cumhuriyet Univ, Fac Med, Dept Gen Surg, TR-58140 Sivas, Turkey -- [Altun, Ahmet -- Bagcivan, Ihsan -- Kaya, Tijen] Cumhuriyet Univ, Fac Med, Dept Pharmacol, TR-58140 Sivas, Turkeyen_US
dc.description.abstractObjectives. To investigate the effects of proton pump inhibitors (PPIs) and H-2 receptor antagonists on ileum motility in rats with peritonitis and compare changes with control group rats. Methods. Peritonitis was induced by cecal ligation and puncture in 8 rats. Another of 8 rats underwent a sham operation and were accepted as controls. Twenty-four hours later after the operation, the rats were killed, and their ileum smooth muscle was excised and placed in circular muscle direction in a 10mL organ bath. Changes in amplitude and frequency of contractions were analyzed before and after PPIs and H-2 receptor blockers. Results. PPI agents decreased the motility in a dose-dependent manner in ileum in both control and intraabdominal sepsis groups. While famotidine had no significant effect on ileum motility, ranitidine and nizatidine enhanced motility in ileum in both control and intraabdominal sepsis groups. This excitatory effect of H-2 receptor antagonists and inhibitor effects of PPIs were significantly high in control group when compared to the peritonitis group. The inhibitor effect of pantoprazole on ileum motility was significantly higher than the other two PPI agents. Conclusions. It was concluded that H-2 receptor antagonists may be more effective than PPIs for recovering the bowel motility in the intraabdominal sepsis situation.en_US
dc.identifier.doi10.1155/2011/218342en_US
dc.identifier.issn1687-6121
dc.identifier.pmid22216022en_US
dc.identifier.scopus2-s2.0-84855593892en_US
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://dx.doi.org/10.1155/2011/218342
dc.identifier.urihttps://hdl.handle.net/20.500.12418/9685
dc.identifier.wosWOS:000298684500001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHINDAWI PUBLISHING CORPORATIONen_US
dc.relation.ispartofGASTROENTEROLOGY RESEARCH AND PRACTICEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEffects of Proton Pump Inhibitors and H-2 Receptor Antagonists on the Ileum Motilityen_US
dc.typeArticleen_US

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