Investigation of acute effects of aflatoxin on rat proximal and distal colon spontaneous contractions

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dc.contributor.authorGursoy, Nevcihan
dc.contributor.authorDurmus, Nedim
dc.contributor.authorBagcivan, Ihsan
dc.contributor.authorSarac, Bulent
dc.contributor.authorParlak, Ahmet
dc.contributor.authorYildirim, Sahin
dc.contributor.authorKaya, Tijen
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:15:05Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:15:05Z
dc.date.issued2008
dc.department[Gursoy, Nevcihan] Cumhuriyet Univ, Fac Engn, Dept Food Engn, TR-58140 Sivas, Turkey -- [Durmus, Nedim -- Bagcivan, Ihsan -- Sarac, Bulent -- Parlak, Ahmet -- Yildirim, Sahin -- Kaya, Tijen] Cumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkeyen_US
dc.description.abstractAflatoxins are one of the most potent toxic, mutagenic, teratogenic, cancerogenic, and immunosuppresive substances that naturally Occurring contaminants of food. There are some studies in various animal species that have reported aflatoxin effects on gastrointestinal systems, but acute effects of aflatoxins have not been clearly investigated. In this Study, we aimed to investigate the acute gastrointestinal effects of total aflatoxin on rat isolated proximal and distal colon. Aflatoxin was given cumulatively at 10(-8) - 10(-5) M concentrations and the amplitude and frequency of proximal and distal colon contractions were increased significantly. In the presence of atropine Sulfate (23.6 nM) and morphine (0.3 mu M) the amplitude and frequency of anatoxin induced spontan contractions in the proximal and distal colon decreased significantly, on the other hand, L-NNA (0.3 mu m) increased contractions' amplitude and frequency significantly in the proximal colon but not in the distal colon. In conclusion, aflatoxin may increase the amplitude and frequency of contractions by increasing muscarinic activity or by decreasing NO synthase and/or release in Proximal colon and by increasing muscarinic activity in the distal colon. These findings of aflatoxin on isolated rat proximal and distal colon may explain their acute gastrointestinal effects in humans and animals. (c) 2008 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.fct.2008.05.028en_US
dc.identifier.endpage2880en_US
dc.identifier.issn0278-6915
dc.identifier.issue8en_US
dc.identifier.pmid18620790en_US
dc.identifier.scopus2-s2.0-47149094621en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage2876en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.fct.2008.05.028
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10335
dc.identifier.volume46en_US
dc.identifier.wosWOS:000258440100041en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofFOOD AND CHEMICAL TOXICOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectaflatoxinen_US
dc.subjectproximal colonen_US
dc.subjectdistal colonen_US
dc.subjectin vitroen_US
dc.titleInvestigation of acute effects of aflatoxin on rat proximal and distal colon spontaneous contractionsen_US
dc.typeArticleen_US

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