Natural essential oils as a new therapeutic tool in colorectal cancer

Basit Öğe Kaydı
dc.authoridSharopov, Farukh/0000-0003-0378-8887
dc.authoridAlarcon-Zapata, Pedro/0000-0003-2236-2064
dc.authoridCalina, Daniela/0000-0002-1523-9116
dc.authoridSharifi-Rad, Javad/0000-0002-7301-8151
dc.authoridLopez, Victor/0000-0001-6969-1055
dc.authoridDarline, Dize/0000-0003-3387-4102
dc.authoridTCHOKOUAHA YAMTHE, Lauve Rachel/0000-0002-7455-3607
dc.contributor.authorGarzoli, Stefania
dc.contributor.authorAlarcon-Zapata, Pedro
dc.contributor.authorSeitimova, Gulnaz
dc.contributor.authorAlarcon-Zapata, Barbara
dc.contributor.authorMartorell, Miquel
dc.contributor.authorSharopov, Farukh
dc.contributor.authorFokou, Patrick Valere Tsouh
dc.date.accessioned2024-10-26T18:11:43Z
dc.date.available2024-10-26T18:11:43Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractColorectal cancer (CRC) is the third most revalent type of cancer in the world and the second most common cause of cancer death (about 1 million per year). Historically, natural compounds and their structural analogues have contributed to the development of new drugs useful in the treatment of various diseases, including cancer. Essential oils are natural odorous products made up of a complex mixture of low molecular weight compounds with recognized biological and pharmacological properties investigated also for the prevention and treatment of cancer. The aim of this paper is to highlight the possible role of essential oils in CRC, their composition and the preclinical studies involving them. It has been reviewed the preclinical pharmacological studies to determine the experimental models used and the anticancer potential mechanisms of action of natural essential oils in CRC. Searches were performed in the following databases PubMed/Medline, Web of science, TRIP database, Scopus, Google Scholar using appropriate MeSH terms. The results of analyzed studies showed that EOs exhibited a wide range of bioactive effects like cytotoxicity, antiproliferative, and antimetastatic effects on cancer cells through various mechanisms of action. This updated review provides a better quality of scientific evidence for the efficacy of EOs as chemotherapeutic/chemopreventive agents in CRC. Future translational clinical studies are needed to establish the effective dose in humans as well as the most suitable route of administration for maximum bioavailability and efficacy. Given the positive anticancer results obtained from preclinical pharmacological studies, EOs can be considered efficient complementary therapies in chemotherapy in CRC.
dc.description.sponsorshipMinistry of Science and Higher Education of the Republic of Kazakhstan [AP08052551]
dc.description.sponsorshipThis work was supported by the Ministry of Science and Higher Education of the Republic of Kazakhstan [Grant number AP08052551].
dc.identifier.doi10.1186/s12935-022-02806-5
dc.identifier.issn1475-2867
dc.identifier.issue1
dc.identifier.pmid36514100
dc.identifier.scopus2-s2.0-85144031235
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1186/s12935-022-02806-5
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30776
dc.identifier.volume22
dc.identifier.wosWOS:000898814000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmc
dc.relation.ispartofCancer Cell International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectColorectal cancer
dc.subjectNatural essential oils
dc.subjectAnticancer properties
dc.subjectCytotoxicity
dc.subjectApoptosis
dc.subjectAnticancer therapy
dc.titleNatural essential oils as a new therapeutic tool in colorectal cancer
dc.typeReview Article

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksyonu
Scopus İndeksli Yayınlar Koleksiyonu